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Lotrel (Amlodipine - benazepril)
Virtual visit

Lotrel (Amlodipine - benazepril)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Lotrel (Amlodipine - benazepril) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Lotrel (Amlodipine - benazepril)?

Lotrel is a combination blood pressure medication containing amlodipine, a calcium channel blocker, and benazepril, an ACE inhibitor. Together, these two medications lower blood pressure through two distinct and complementary mechanisms, providing greater reduction than either drug alone. Amlodipine relaxes the walls of blood vessels by blocking calcium entry into smooth muscle cells, while benazepril reduces the production of angiotensin II—a potent vasoconstrictor and driver of fluid retention. Combining them in one tablet simplifies the regimen and improves adherence for patients who need dual therapy. It's taken once daily.

Dual complementary blood pressure reduction

Amlodipine blocks calcium channels in vascular smooth muscle to cause direct vasodilation, while benazepril inhibits ACE to reduce angiotensin II production—attacking hypertension through two independent and additive pathways simultaneously.

ACE inhibitor kidney protection

Benazepril reduces intraglomerular pressure and protein leakage, providing kidney-protective benefits beyond blood pressure control—particularly valuable for hypertensive patients with diabetes or early chronic kidney disease.

Single-tablet adherence benefit

Combining a CCB and ACE inhibitor in one pill reduces daily pill count and the risk of forgetting individual medications—improving long-term adherence in patients who require dual therapy to achieve blood pressure targets.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

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Frequently Asked Questions

Why were two blood pressure medications combined in one pill?

Combining amlodipine and benazepril in a single capsule simplifies the regimen, reduces daily pill count, and improves long-term adherence — particularly important for blood pressure control that requires two complementary drug classes.

How do the two components of Lotrel work together?

Amlodipine relaxes blood vessel walls by blocking calcium entry, while benazepril reduces angiotensin II production — attacking blood pressure through two independent pathways simultaneously for greater combined effect.

What are the kidney benefits of Lotrel?

The benazepril component provides kidney-protective effects — reducing intraglomerular pressure and protein leakage — particularly relevant for patients with diabetes or early chronic kidney disease who are at elevated risk.

What side effects might I experience?

Ankle swelling from amlodipine, dizziness especially when standing, dry cough from benazepril, and elevated potassium are the most commonly reported effects. The cough is the most frequent reason people switch from ACE inhibitors to ARBs.

Can I take Lotrel during pregnancy?

No. Benazepril — the ACE inhibitor component — is contraindicated in pregnancy and can cause serious fetal harm. Stop immediately and contact your clinician if pregnancy occurs while taking Lotrel.
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