Contrave

Brand for bupropion

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With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Contrave®?

Contrave® is a prescription medication that combines two medicines—bupropion and naltrexone—to support weight loss. It's designed for people who struggle with appetite, cravings, or emotional eating and want additional help alongside lifestyle changes.

Taken twice daily by mouth (two tablets in the morning, two in the evening), Contrave® helps reduce appetite and manage cravings over time. The dose starts low and gradually increases over four weeks to minimize side effects and help your body adjust.

Contrave® affects the parts of the brain involved in hunger, reward, and cravings. Over time, it can help reduce appetite and make cravings easier to manage.

Targets hunger in the hypothalamus

The brain's appetite control center—helping you feel satisfied with less food and reducing the drive to eat between meals.

Reduces cravings through the reward system

By affecting the parts of the brain that create those hard-to-resist urges for specific foods, especially during times of stress or boredom.

Works differently than GLP-1s

While medications like Wegovy® or Saxenda® slow digestion and work through gut hormones, Contrave® acts directly in the brain—which means it may work for people who haven't had success with other weight-loss medications.

Supports sustainable changes

Weight loss isn't just about willpower. Biology plays a big role in hunger and cravings. Having medical support can make healthy changes feel more doable and more sustainable.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

Thousands of customers trust us

“I feel like I'm finally on the right path to improving my health with the right support now! It's so refreshing and reassuring.”

—Emerald, Texas

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—Kaylee, Louisiana

“I couldn't be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

—Nika, Tennessee

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