General
Contrave (Bupropion - naltrexone)
Virtual visit

Contrave (Bupropion - naltrexone)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Contrave (Bupropion - naltrexone) or a refill of an existing one.

Non-stimulant, non-GLP-1 option that targets hunger and cravings in the brain's appetite and reward centers

Combines two established medications—bupropion and naltrexone—that work together to reduce appetite and make cravings easier to manage

Prescribed only if appropriate, with ongoing medical support

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Contrave®?

Contrave® is a prescription medication that combines two medicines—bupropion and naltrexone—to support weight loss. It's designed for people who struggle with appetite, cravings, or emotional eating and want additional help alongside lifestyle changes.

Taken twice daily by mouth (two tablets in the morning, two in the evening), Contrave® helps reduce appetite and manage cravings over time. The dose starts low and gradually increases over four weeks to minimize side effects and help your body adjust.

Contrave® affects the parts of the brain involved in hunger, reward, and cravings. Over time, it can help reduce appetite and make cravings easier to manage.

Targets hunger in the hypothalamus

The brain's appetite control center—helping you feel satisfied with less food and reducing the drive to eat between meals.

Reduces cravings through the reward system

By affecting the parts of the brain that create those hard-to-resist urges for specific foods, especially during times of stress or boredom.

Works differently than GLP-1s

While medications like Wegovy® or Saxenda® slow digestion and work through gut hormones, Contrave® acts directly in the brain—which means it may work for people who haven't had success with other weight-loss medications.

Supports sustainable changes

Weight loss isn't just about willpower. Biology plays a big role in hunger and cravings. Having medical support can make healthy changes feel more doable and more sustainable.

Virtual visit with clinician

Ongoing support, always available.

You’ll be treated by experts with years of experience in managing weight, metabolic health, and related conditions such as hypertension and insulin resistance.

Our clinicians will monitor progress. If medication is prescribed, we will adjust dosing and manage side effects safely. If lab testing is ordered, we review results and refine your plan accordingly. You’re never left navigating alone.

Contrave (Bupropion - naltrexone)

How Contrave® can change your day-to-day

Cravings that feel manageable

Many people describe feeling less preoccupied with food—fewer moments where a craving feels impossible to ignore, and more mental space for other things.

A routine that becomes automatic

Taking two tablets twice a day becomes second nature, much like any other daily medication—simple, consistent, and easy to remember.

Support that makes lifestyle changes feel realistic

When hunger and cravings aren't constantly getting in the way, the healthy choices you're trying to make—eating better, moving more—start to feel less like a battle.

With General Medicine, weight loss is a part of your long-term care plan.

Whether you want access to a GLP-1 or a more comprehensive approach, you’ll always start with an expert clinician. They evaluate your full health history, lifestyle, and past weight-loss attempts to build a plan designed for long-term health.

Your care plan
Clinician
1

Share your health story

Complete a brief medical questionnaire so our clinicians can understand your goals, history, and unique challenges.

2

Meet your clinician

Book a virtual weight-loss visit with a licensed physician who evaluates your needs and determines if medication is right for you. It’s covered by insurance.

3

Get your care plan

If eligible, your clinician will prescribe the most appropriate treatment—GLP-1 or non-GLP-1. They’ll also help you manage related conditions such as hypertension or metabolic syndrome.

4

Start seeing results

Track your progress, schedule follow-up visits anytime, and adjust your treatment as your body evolves.

Clinical outcomes and care4.1%
In clinical trials, adults with obesity taking Contrave® lost 4.1% more weight than those on placebo when used alongside diet and exercise.

Patients without diabetes lost, on average, 4.1% more body weight compared with placebo over one year. Among patients taking Contrave®, 42% lost at least 5% of their body weight compared to only 17% with placebo.

Patients with type 2 diabetes lost, on average, 2% more body weight over the same time period, with 36% achieving at least 5% weight loss compared to 18% with placebo.

What our customers have to say

Hear from people who felt heard, understood, and supported on General Medicine's weight loss program

“General Medicine helped me accomplish what I couldn't do alone, and was always there if I had a question.”

Melinda

“With regular checkups and consistent guidance, I was able to improve my blood pressure, maintain healthier blood sugar levels, and build better daily habits around nutrition and exercise. Having ongoing support and preventive care made it easier to stay accountable and make steady progress toward a healthier lifestyle.”

Brandy

“It was so simple to access the care that I needed to improve my health and life.”

Brandon

“I love the easy access and flexible appointments. The communication and how they always check in for you is a big thing.”

Waldo

Start your clinician-led weight-loss journey today.

Frequently asked questions about Contrave®

How does Contrave® actually help with weight loss?

Contrave® doesn't speed up metabolism or burn fat on its own. Instead, it helps quiet appetite and reduce cravings, which can make it easier to eat less without feeling constantly hungry or deprived. That support can make long-term changes feel more realistic.

How long does it take to see results?

Some people notice changes in appetite within a few weeks, but meaningful weight loss usually builds over several months. Progress is gradual, and results vary. Your clinician will help track how it's working and decide whether it's worth continuing. You should evaluate your progress at 12 weeks—if you haven't lost at least 4-5% of your starting weight by then, the medication may not be working for you.

What side effects should I expect early on?

Common side effects include nausea, headache, constipation, dry mouth, or trouble sleeping, especially during the dose ramp-up. These often improve as your body adjusts. Starting slowly is intentional and helps reduce discomfort. More serious but less common risks include increased blood pressure or heart rate, liver problems, and seizures (especially in people with a history of seizures or eating disorders). Because Contrave® contains bupropion (an antidepressant), it carries a boxed warning about increased risk of suicidal thoughts and behaviors—you and your family should watch for changes in mood or behavior, especially when starting treatment or changing doses.

Can I take Contrave® if I'm on other medications?

Contrave® has several important drug interactions. You cannot take it if you're currently using opioid pain medications, taking other medications that contain bupropion (like Wellbutrin®), or if you've taken MAOIs in the past 14 days. You also cannot take it if you're dependent on opioids or in opioid withdrawal. Your clinician will review your full medication list to make sure Contrave® is safe for you.

Is Contrave® the same as an antidepressant or a smoking cessation medication?

No. While Contrave® contains bupropion (which is used as an antidepressant under the brand name Wellbutrin® and for smoking cessation under the brand name Zyban®), Contrave® is not approved for treating depression or helping people quit smoking. The combination of bupropion and naltrexone in Contrave® is specifically designed for weight loss and works differently than either medication alone

Will insurance cover Contrave®?

Insurance coverage varies significantly by plan. Contrave® is sometimes covered by commercial insurance for weight loss, though prior authorization is often required. Medicare Part D generally does not cover weight-loss medications. Coverage also depends on whether you meet specific criteria (BMI thresholds, documented weight-related health conditions, evidence of trying other weight-loss methods first). Our team can help you navigate your insurance options and explore manufacturer savings programs if available.
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