General
Auvelity (Dextromethorphan - bupropion)
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Auvelity (Dextromethorphan - bupropion)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Auvelity (Dextromethorphan - bupropion) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Auvelity (Dextromethorphan - bupropion)?

Auvelity is a prescription combination medication approved for major depressive disorder in adults, pairing dextromethorphan (DXM)—an NMDA glutamate receptor antagonist—with bupropion, which both enhances DXM's CNS activity and provides its own antidepressant effects. The combination represents a new mechanism for treating depression: targeting the glutamate system rather than solely focusing on serotonin, dopamine, or norepinephrine. Bupropion inhibits the enzyme that rapidly breaks down DXM, allowing it to reach therapeutic brain levels for antidepressant effect. Auvelity is taken twice daily and demonstrated faster onset of action in clinical trials—with some patients experiencing improvement within one week.

NMDA receptor antagonism

Dextromethorphan blocks NMDA glutamate receptors in the brain, modulating excitatory neurotransmission and promoting synaptic plasticity—a depression treatment mechanism distinct from all existing monoamine-based antidepressants.

Bupropion as pharmacokinetic enhancer

Bupropion inhibits CYP2D6, the enzyme that rapidly metabolizes DXM, dramatically extending its half-life and allowing DXM to reach brain concentrations sufficient for antidepressant effect—while also contributing its own dopamine and norepinephrine reuptake inhibition.

Faster antidepressant onset

Clinical trials showed meaningful symptom improvement in some patients within the first week—faster than the typical 4–6 week onset of standard antidepressants—which may be clinically significant for patients in acute depressive episodes.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

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Frequently Asked Questions

How is Auvelity different from standard antidepressants?

Auvelity targets the glutamate system through NMDA receptor antagonism — a completely different mechanism from all SSRIs, SNRIs, and other approved antidepressants. This novel approach may benefit patients who haven't responded to existing treatments.

Why does Auvelity contain bupropion?

Bupropion inhibits CYP2D6 — the enzyme that rapidly breaks down dextromethorphan — allowing DXM to reach brain concentrations sufficient for antidepressant effect. Bupropion also provides its own dopamine and norepinephrine reuptake inhibition.

How quickly does Auvelity start working?

Clinical trials showed some patients noticing improvement within the first week — significantly faster than the 4–6 week onset of SSRIs and SNRIs. Not all patients respond this quickly, but early response is a clinically notable feature.

What side effects might I experience?

Dizziness, headache, diarrhea, dry mouth, sexual dysfunction, and somnolence are the most commonly reported effects. The bupropion component also lowers the seizure threshold at higher doses — an important consideration.

Can I take Auvelity with other antidepressants?

Use caution. Auvelity's serotonergic activity through DXM creates a risk of serotonin syndrome when combined with other serotonergic medications. MAO inhibitors are contraindicated. A clinician review of all medications is essential before prescribing.
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