General
Zanaflex (Tizanidine)
Virtual visit

Zanaflex (Tizanidine)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Zanaflex (Tizanidine) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Zanaflex (Tizanidine)?

Zanaflex is a short-acting muscle relaxant prescribed to treat spasticity—the muscle stiffness, spasms, and increased muscle tone associated with conditions like multiple sclerosis and spinal cord injury. It works in the spinal cord by activating alpha-2 adrenergic receptors, which reduces the release of excitatory neurotransmitters that drive muscle overactivity. Because its effects last only 3–6 hours, it's typically timed to provide relief during specific activities like physical therapy or sleep. It causes significant sedation and blood pressure lowering, so doses are carefully titrated.

Alpha-2 adrenergic agonism

Activates alpha-2 receptors in the spinal cord, reducing the release of excitatory amino acids like glutamate and aspartate that drive the hyperreflexia and excessive muscle tone behind spasticity.

Short-acting targeted relief

Its 3–6 hour duration allows dosing to be timed strategically—providing muscle relaxation during specific periods of activity, therapy, or rest without continuous sedation throughout the day.

Spinal cord and MS spasticity

Particularly effective for the neurologically driven spasticity of multiple sclerosis and spinal cord injury, where overactive spinal reflex arcs cause painful, disabling muscle stiffness and involuntary spasms.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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Frequently Asked Questions

How quickly does Zanaflex work for muscle spasticity?

Tizanidine is a short-acting medication — it typically begins reducing muscle tone and spasm within 1–2 hours of a dose and lasts 3–6 hours, making it practical to time around specific activities.

Can I use Zanaflex as needed or do I have to take it regularly?

Zanaflex can be used on a scheduled basis or strategically timed before activities that worsen spasticity — like physical therapy or sleep. Your clinician will advise on the best approach for your specific situation.

Can I stop Zanaflex suddenly?

Stopping tizanidine abruptly — particularly at higher doses — can cause rebound hypertension, tachycardia, and increased spasticity. Always taper gradually under your clinician's guidance when discontinuing.

What side effects might I experience?

Drowsiness, dizziness, weakness, dry mouth, and low blood pressure are the most common effects. Liver toxicity has occurred rarely — baseline liver function testing may be recommended before starting.

Does Zanaflex interact with other medications?

Yes — significant interactions exist with fluvoxamine and ciprofloxacin, which can dramatically increase tizanidine levels and cause dangerous low blood pressure. Always inform your clinician of all medications before starting.
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