Xifaxan

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Most insurance accepted

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Available nationwide

What is Xifaxan?

Xifaxan is a rifamycin-class antibiotic that works almost entirely within the gastrointestinal tract—it's minimally absorbed into the bloodstream, so its activity is concentrated where it's needed most. It's used to treat traveler's diarrhea caused by E. coli, to reduce episodes of hepatic encephalopathy (confusion and cognitive decline caused by liver disease), and to treat irritable bowel syndrome with diarrhea (IBS-D). Its gut-limited action allows it to alter the intestinal bacterial environment without the systemic side effects of conventional antibiotics.

Gut-selective antibiotic action

Xifaxan is less than 0.4% absorbed after oral dosing, concentrating its antibacterial effects entirely within the intestinal tract — disrupting bacterial RNA synthesis locally without meaningful systemic antibiotic exposure.

Hepatic encephalopathy prevention

Reduces ammonia-producing bacteria in the gut, lowering the blood ammonia levels that accumulate in liver disease and trigger the confusion, disorientation, and cognitive decline of hepatic encephalopathy.

IBS-D microbiome modulation

Appears to reduce small intestinal bacterial overgrowth and normalize gut microbiome composition, reducing bloating, abdominal pain, and diarrhea in People with IBS-D — effects that can persist for weeks after a short treatment course.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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