Logo
Xifaxan (rifaximin)
Virtual visit

Xifaxan (rifaximin)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Xifaxan (rifaximin) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Xifaxan (rifaximin)?

Xifaxan is a rifamycin-class antibiotic that works almost entirely within the gastrointestinal tract—it's minimally absorbed into the bloodstream, so its activity is concentrated where it's needed most. It's used to treat traveler's diarrhea caused by E. coli, to reduce episodes of hepatic encephalopathy (confusion and cognitive decline caused by liver disease), and to treat irritable bowel syndrome with diarrhea (IBS-D). Its gut-limited action allows it to alter the intestinal bacterial environment without the systemic side effects of conventional antibiotics.

Gut-selective antibiotic action

Rifaximin is less than 0.4% absorbed after oral dosing, concentrating its antibacterial effects entirely within the intestinal tract—disrupting bacterial RNA synthesis locally without meaningful systemic antibiotic exposure.

Hepatic encephalopathy prevention

Reduces ammonia-producing bacteria in the gut, lowering the blood ammonia levels that accumulate in liver disease and trigger the confusion, disorientation, and cognitive decline of hepatic encephalopathy.

IBS-D microbiome modulation

Appears to reduce small intestinal bacterial overgrowth and normalize gut microbiome composition, reducing bloating, abdominal pain, and diarrhea in IBS-D patients—effects that can persist for weeks after a short treatment course.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How is Xifaxan different from regular antibiotics?

Xifaxan is minimally absorbed into the bloodstream — it works almost entirely within the intestinal tract. This means it can treat gut infections and modify gut bacteria with significantly less systemic antibiotic exposure.

How long does a course of Xifaxan last for IBS-D?

For IBS with diarrhea, Xifaxan is typically prescribed as a 14-day course. Interestingly, the benefits on bloating and diarrhea can persist for several weeks after the course is completed.

Can I take Xifaxan repeatedly if my IBS symptoms return?

Yes. For IBS-D, repeat courses are used when symptoms recur. The gut-limited mechanism and low resistance potential make repeat treatment more feasible than with systemic antibiotics.

What side effects might I experience?

Because Xifaxan is minimally absorbed, systemic side effects are uncommon. Nausea, flatulence, and abdominal pain can occur but are generally mild. The limited systemic exposure also means few drug interactions.

Is Xifaxan effective for traveler's diarrhea prevention?

Xifaxan is approved for treatment of traveler's diarrhea caused by E. coli, not for prevention. For prevention, other strategies including food/water precautions and bismuth subsalicylate are typically recommended.
Logo

© 2026 Path Healthcare Systems Corp.