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Xenical (orlistat)
Virtual visit

Xenical (orlistat)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Xenical (orlistat) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Xenical (orlistat)?

Xenical is a prescription weight loss medication that works by blocking the digestion and absorption of dietary fat in the gastrointestinal tract. Unlike centrally acting weight loss drugs that suppress appetite or affect the brain, Orlistat works entirely within the gut—inhibiting pancreatic lipase enzymes so that about one-third of the fat consumed in a meal passes through the digestive system unabsorbed. It's taken with each main meal containing fat and is used alongside a reduced-calorie diet and exercise. The unabsorbed fat that passes through can cause oily or loose stools, particularly if a high-fat meal is eaten.

Pancreatic lipase inhibition

Blocks pancreatic and gastric lipase enzymes that break down dietary triglycerides into absorbable fatty acids and monoglycerides—preventing approximately 30% of consumed fat from being digested and absorbed.

Gut-localized mechanism

Works entirely within the gastrointestinal tract without entering the bloodstream in significant amounts, avoiding the cardiovascular and CNS side effects associated with systemic weight loss medications.

Dietary fat consequence

Unabsorbed fat passes into the large intestine and is excreted, which reinforces reduced fat intake—the oily, loose stools that can result from high-fat meals serve as a practical behavioral feedback mechanism encouraging adherence to a lower-fat diet.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How much fat does Xenical actually block?

Xenical blocks the digestion and absorption of approximately one-third of the fat consumed in a meal. The unabsorbed fat passes through the intestine and is excreted in the stool rather than being stored.

Do I need to follow a specific diet while on Xenical?

Yes. A low-fat diet — with no more than 30% of calories from fat — is essential. High-fat meals significantly worsen GI side effects and undermine the weight loss benefit. Dividing fat evenly across meals also helps.

How much weight loss can I expect from Xenical?

Clinical trials showed approximately 5–7% body weight loss over one year alongside diet and exercise — modest but clinically meaningful when sustained. Xenical is a tool, not a standalone solution.

What side effects might I experience?

Oily or fatty stools, urgent need to defecate, oily spotting, gas with discharge, and fecal incontinence are the most distinctive side effects — directly caused by the unabsorbed fat. These are worst when high-fat meals are eaten.

Does Xenical affect absorption of vitamins?

Yes. Because it reduces fat absorption, Xenical can also reduce absorption of fat-soluble vitamins A, D, E, and K. A daily multivitamin containing these vitamins should be taken — at least 2 hours before or after Xenical.
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