Vyleesi

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What is Vyleesi?

Vyleesi is a prescription injectable medication approved for premenopausal women with hypoactive sexual desire disorder (HSDD)—a condition marked by persistently low sexual desire that causes personal distress. Unlike Addyi, which is taken daily, Vyleesi is used on-demand—injected into the abdomen or thigh 45 minutes before anticipated sexual activity and used no more than once per 24 hours. It works by activating melanocortin receptors in the brain that are involved in sexual motivation and arousal. The most common side effect is temporary nausea after injection.

Melanocortin receptor activation

Activates MC3R and MC4R receptors in the central nervous system, stimulating neural pathways associated with sexual motivation and arousal through a mechanism distinct from hormonal or vascular treatments.

On-demand dosing

Taken only when desired, 45 minutes before sexual activity—offering a situational approach to HSDD for women who prefer not to take a daily medication or who don't respond to Addyi.

Non-hormonal brain-based mechanism

Works through the central nervous system's melanocortin system rather than sex hormones, making it an option for women who want or need to avoid estrogen- or testosterone-based therapies.

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Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

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