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Vosevi (Sofosbuvir - velpatasvir - voxilaprevir)
Virtual visit

Vosevi (Sofosbuvir - velpatasvir - voxilaprevir)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Vosevi (Sofosbuvir - velpatasvir - voxilaprevir) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Vosevi (Sofosbuvir - velpatasvir - voxilaprevir)?

Vosevi is a once-daily single-tablet regimen combining three direct-acting antiviral agents used to treat chronic hepatitis C infection across all major genotypes (1–6), particularly in patients who have been previously treated with certain other hepatitis C regimens. Each component targets a different protein the hepatitis C virus needs to replicate, making it extremely difficult for the virus to develop resistance. Treatment is typically 8 or 12 weeks in duration. Cure rates—defined as undetectable virus 12 weeks after completing treatment—are consistently above 95%, representing a remarkable transformation in the treatment of what was once a lifelong chronic illness.

Triple direct-acting antiviral mechanism

Sofosbuvir inhibits NS5B polymerase, velpatasvir blocks NS5A protein, and voxilaprevir inhibits NS3/4A protease—three essential viral enzymes targeted simultaneously, making resistance essentially impossible with consistent adherence.

Pan-genotypic coverage

Effective against all major hepatitis C genotypes (1 through 6) in a single fixed-dose regimen, eliminating the need for genotype-specific treatment selection and simplifying care across diverse patient populations.

High cure rate re-treatment option

Specifically developed for patients who have failed previous NS5A inhibitor-containing regimens—providing a rescue option with sustained virologic response (cure) rates above 95% even in this difficult-to-treat population.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

What is Vosevi used for?

Vosevi is a complete once-daily hepatitis C treatment approved for adults with all major HCV genotypes — particularly those who have previously been treated with NS5A inhibitor-containing regimens and need a rescue option.

How effective is Vosevi at curing hepatitis C?

Sustained virologic response (cure) rates with Vosevi consistently exceed 95% — even in patients who failed previous treatment — representing one of the highest cure rates in the history of infectious disease treatment.

How long is the Vosevi treatment course?

Most patients complete treatment in 8 or 12 weeks — determined by HCV genotype, treatment history, and whether cirrhosis is present. Your clinician will specify the appropriate duration based on your situation.

What side effects might I experience?

Headache, fatigue, nausea, and diarrhea are most commonly reported — generally mild. Vosevi can reactivate hepatitis B in patients with prior HBV infection, so HBV testing is required before starting treatment.

Will I need follow-up testing after completing Vosevi?

Yes. A hepatitis C viral load test is performed 12 weeks after completing treatment to confirm sustained virologic response — the definition of cure. A negative result at this point means the infection has been eliminated.
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