Vivotif (typhoid vaccine)
Taken at home before travel, rather than needing an injection, Vivotif is an oral typhoid vaccine. After you book, your clinician reviews your history so your visit is about finding the right fit for you, whether that's Vivotif or another option.
No injections — four oral capsules taken at home before travel
Provides up to 5 years of typhoid protection
Completed at least one week before travel to endemic regions
Visit options
We'll check any insurance and show you your options before you book.
Video Visit
$25
Est. or $100 w/o insurance
Chat Visit
$30
w/o insurance
Most insurance accepted
Board-certified clinicians
No hidden fees
Available nationwide
What is Vivotif?
Vivotif is an oral vaccine used to protect against typhoid fever—a serious bacterial infection caused by Salmonella typhi, transmitted through contaminated food and water in regions with poor sanitation. Unlike injectable typhoid vaccines, Vivotif is a live attenuated (weakened) bacterial vaccine taken as a series of four capsules on alternating days, completed at least one week before potential exposure. It works by stimulating an immune response in the intestinal tract—the primary entry point for typhoid bacteria—providing localized mucosal immunity as well as systemic protection.
Live attenuated intestinal immunity
Contains a weakened but live strain of S. typhi that colonizes the gut briefly, triggering a robust local and systemic immune response without causing disease—preparing the immune system to recognize and fight real typhoid infection.
Mucosal immune activation
Stimulates IgA antibody production in the intestinal lining—the first line of defense against S. typhi entry—providing immune protection at the exact site where typhoid bacteria enter the body.
Oral convenience and compliance
Four-capsule regimen taken at home on alternating days offers a needle-free alternative to injectable typhoid vaccines, with protective immunity lasting approximately 5 years before revaccination is recommended.
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Talk to a clinician about typhoid vaccination before you travel
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Frequently asked questions
How do I take the Vivotif vaccine?
Vivotif is taken as four oral capsules on alternating days — days 1, 3, 5, and 7. The series must be completed at least 1 week before potential typhoid exposure for full protective effect. Missing this spacing or timing can reduce how well the vaccine series actually protects you.
How long does the Vivotif vaccine protect against typhoid?
Protection from a full course of Vivotif lasts approximately 5 years. If continued risk exists after that period, the full four-capsule series should be repeated. Your clinician can advise on timing if you expect ongoing or repeated typhoid exposure risk.
How should I store the Vivotif capsules?
Vivotif must be refrigerated at all times — it contains live bacteria that are temperature-sensitive. Do not freeze. Take each capsule from the refrigerator immediately before use. Losing refrigeration for an extended period can reduce the vaccine's effectiveness, so plan your storage carefully.
Can I take antibiotics while completing the Vivotif series?
No. Antibiotics can kill the live bacterial vaccine and prevent it from generating an immune response. Avoid antibiotics for at least 3 days before starting and during the vaccination series. Planning your antibiotic timing around the vaccine series is an important part of scheduling this properly.
Are there any side effects from Vivotif?
Since it is a live vaccine taken orally, mild GI effects — nausea, stomach discomfort, and diarrhea — can occur. These are generally short-lived. Fever is rare but has been reported. Contact your clinician if symptoms feel severe or don't improve within a few days.