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Vivotif Typhoid Vaccine (Salmonella typhi Ty21a live antigen)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Vivotif Typhoid vaccine (Salmonella typhi Ty21a live antigen) or a refill of an existing one.

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Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

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$25

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$30

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What is Vivotif?

Vivotif is an oral vaccine used to protect against typhoid fever—a serious bacterial infection caused by Salmonella typhi, transmitted through contaminated food and water in regions with poor sanitation. Unlike injectable typhoid vaccines, Vivotif is a live attenuated (weakened) bacterial vaccine taken as a series of four capsules on alternating days, completed at least one week before potential exposure. It works by stimulating an immune response in the intestinal tract—the primary entry point for typhoid bacteria—providing localized mucosal immunity as well as systemic protection.

Live attenuated intestinal immunity

Contains a weakened but live strain of S. typhi that colonizes the gut briefly, triggering a robust local and systemic immune response without causing disease—preparing the immune system to recognize and fight real typhoid infection.

Mucosal immune activation

Stimulates IgA antibody production in the intestinal lining—the first line of defense against S. typhi entry—providing immune protection at the exact site where typhoid bacteria enter the body.

Oral convenience and compliance

Four-capsule regimen taken at home on alternating days offers a needle-free alternative to injectable typhoid vaccines, with protective immunity lasting approximately 5 years before revaccination is recommended.

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

What our customers have to say

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Frequently asked questions

How do I take the Vivotif vaccine?

Vivotif is taken as four oral capsules on alternating days — days 1, 3, 5, and 7. The series must be completed at least 1 week before potential typhoid exposure for full protective effect.

How long does the Vivotif vaccine protect against typhoid?

Protection from a full course of Vivotif lasts approximately 5 years. If continued risk exists after that period, the full four-capsule series should be repeated.

How should I store the Vivotif capsules?

Vivotif must be refrigerated at all times — it contains live bacteria that are temperature-sensitive. Do not freeze. Take each capsule from the refrigerator immediately before use.

Are there any side effects from Vivotif?

Since it is a live vaccine taken orally, mild GI effects — nausea, stomach discomfort, and diarrhea — can occur. These are generally short-lived. Fever is rare but has been reported.

Can I take antibiotics while completing the Vivotif series?

No. Antibiotics can kill the live bacterial vaccine and prevent it from generating an immune response. Avoid antibiotics for at least 3 days before starting and during the vaccination series.