Tri-Luma

Brand for hydroquinone

Without insurance

With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Tri-Luma?

Tri-Luma is a prescription topical cream containing three active ingredients—fluocinolone (a corticosteroid), hydroquinone (a skin lightener), and tretinoin (a retinoid)—specifically formulated to treat melasma, a condition that causes brown or gray-brown patches on the face. Each ingredient addresses a different aspect of the condition: hydroquinone reduces melanin production, tretinoin increases skin cell turnover to fade existing pigment, and fluocinolone reduces the inflammation that can worsen discoloration. It's applied once nightly and used alongside strict sun protection.

Triple-action pigment correction

Hydroquinone inhibits the enzyme tyrosinase to reduce new melanin production, tretinoin accelerates the shedding of pigmented skin cells, and fluocinolone calms inflammation that drives melanin overproduction—all three mechanisms working together.

Retinoid-enhanced cell turnover

Tretinoin speeds up epidermal renewal, bringing fresh, less-pigmented cells to the surface faster while also enhancing penetration of the other active ingredients into the skin.

Anti-inflammatory stabilization

The corticosteroid component reduces post-inflammatory hyperpigmentation—a common driver of melasma worsening—while also helping the skin tolerate the potentially irritating effects of hydroquinone and tretinoin together.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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