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Trexall (Methotrexate)
Virtual visit

Trexall (Methotrexate)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Trexall (Methotrexate) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Trexall (Methotrexate)?

Trexall is a prescription medication used at low doses to treat autoimmune conditions including rheumatoid arthritis, psoriatic arthritis, and psoriasis, and at higher doses as a chemotherapy agent for certain cancers. For autoimmune disease, it works by suppressing the overactive immune response that attacks the body's own tissues—reducing joint inflammation, skin plaques, and long-term structural damage. It's taken once weekly (not daily) as a tablet, and requires regular blood monitoring to watch for effects on the liver and blood cell counts. Folic acid is typically taken alongside it to reduce side effects.

Folate pathway inhibition

Blocks dihydrofolate reductase, impairing DNA synthesis and cell replication—at low doses this selectively suppresses rapidly proliferating immune cells driving autoimmune inflammation; at higher doses it targets cancer cells.

Disease-modifying anti-inflammatory effect

Reduces the production of inflammatory cytokines and suppresses the immune cell activity responsible for joint destruction in rheumatoid arthritis and skin inflammation in psoriasis—slowing disease progression over time.

Once-weekly dosing with monitoring

Taken just once per week to minimize toxicity, with regular blood tests to monitor liver function and blood cell counts—and folic acid supplementation to help offset common side effects like nausea and mouth sores.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

Why is Trexall taken only once a week, not daily?

Once-weekly dosing is essential for safety — taking it daily at the doses used for autoimmune conditions would cause serious toxicity. Always take it on the same designated day each week and never more than once per week.

Why do I need to take folic acid with Trexall?

Methotrexate interferes with folate metabolism in human cells as well as the immune cells it targets. Folic acid supplementation helps protect normal cells from this effect and reduces side effects including mouth sores and nausea.

What lab tests are required while on Trexall?

Regular monitoring of liver function, complete blood count, and kidney function is required — typically every 1–3 months. These tests catch potential toxicity before serious complications develop.

What side effects might I experience?

Nausea, fatigue, mouth sores, and headache are most common. More serious effects include liver toxicity, bone marrow suppression, and lung inflammation — monitored through regular blood tests and symptom reporting.

Is Trexall safe during pregnancy?

No. Methotrexate is teratogenic and causes miscarriage and birth defects. Effective contraception is required for both men and women during treatment and for several months after stopping. Never take it if pregnant.
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