Trazodone

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What is Trazodone?

Trazodone is an antidepressant that is now most commonly prescribed at lower doses for insomnia—particularly for people who struggle to fall asleep or stay asleep. At the doses used for sleep, its sedating properties take center stage, while its antidepressant effects become more relevant at higher doses. It works by affecting serotonin and histamine receptors in the brain. Unlike many sleep medications, Trazodone is not classified as a controlled substance and doesn't carry the same risk of dependence, making it a frequently chosen option for longer-term sleep support.

Serotonin and histamine modulation

Blocks certain serotonin receptors and histamine receptors in the brain, producing sedation and reducing the hyperarousal that prevents restful sleep—without the dependency profile of benzodiazepines or Z-drugs.

Non-addictive sleep support

Because Trazodone is not a controlled substance, it can be used more freely for chronic sleep difficulties without the prescribing restrictions or dependency concerns associated with traditional sedative-hypnotics.

Dual-purpose flexibility

At lower doses it functions primarily as a sleep aid; at higher doses it acts as a full antidepressant—giving prescribers flexibility to address both mood and sleep within a single medication when both are present.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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