General
Trazodone (Desyrel)
Virtual visit

Trazodone (Desyrel)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Trazodone (Desyrel) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Trazodone (Desyrel)?

Trazodone is an antidepressant that is now most commonly prescribed at lower doses for insomnia—particularly for people who struggle to fall asleep or stay asleep. At the doses used for sleep, its sedating properties take center stage, while its antidepressant effects become more relevant at higher doses. It works by affecting serotonin and histamine receptors in the brain. Unlike many sleep medications, Trazodone is not classified as a controlled substance and doesn't carry the same risk of dependence, making it a frequently chosen option for longer-term sleep support.

Serotonin and histamine modulation

Blocks certain serotonin receptors and histamine receptors in the brain, producing sedation and reducing the hyperarousal that prevents restful sleep—without the dependency profile of benzodiazepines or Z-drugs.

Non-addictive sleep support

Because Trazodone is not a controlled substance, it can be used more freely for chronic sleep difficulties without the prescribing restrictions or dependency concerns associated with traditional sedative-hypnotics.

Dual-purpose flexibility

At lower doses it functions primarily as a sleep aid; at higher doses it acts as a full antidepressant—giving prescribers flexibility to address both mood and sleep within a single medication when both are present.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

Is trazodone primarily for sleep or depression?

It depends on the dose. At lower doses (25–100 mg), the sedating effect is prominent and it's primarily used for sleep. At higher doses, it functions as a full antidepressant. Your clinician will prescribe based on your needs.

How quickly does trazodone work for sleep?

Most people notice improved sleep onset within the first few nights of use. Unlike antidepressant effects which take weeks, the sedating properties work relatively quickly from the start.

Is trazodone habit-forming?

Trazodone is not a controlled substance and is not considered habit-forming or addictive — a key advantage over benzodiazepines and Z-drugs for sleep. Physical dependence at usual doses is not a significant concern.

What side effects might I experience?

Drowsiness, dizziness, dry mouth, and blurred vision are most common. A rare but notable side effect in men is priapism — a prolonged painful erection that requires immediate medical attention if it occurs.

Can I take trazodone long-term for sleep?

Yes. Because it's non-addictive and not a controlled substance, trazodone can be used longer-term for chronic sleep difficulties — a significant advantage over most prescription sleep medications.
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