General
Tradjenta (Linagliptin)
Virtual visit

Tradjenta (Linagliptin)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Tradjenta (Linagliptin) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Tradjenta (Linagliptin)?

Tradjenta is a DPP-4 inhibitor used to improve blood sugar control in adults with Type 2 diabetes. It works by blocking the enzyme that rapidly breaks down incretin hormones GLP-1 and GIP, allowing these natural hormones to remain active longer and stimulate insulin release in a glucose-dependent way. A distinguishing feature of Linagliptin is that it's primarily eliminated through the bile and feces rather than the kidneys—making it the only DPP-4 inhibitor that doesn't require dose adjustment in patients with kidney disease. It's taken as a once-daily tablet and is weight-neutral with a low risk of hypoglycemia.

DPP-4 enzyme inhibition

Blocks dipeptidyl peptidase-4, extending the activity of GLP-1 and GIP incretin hormones that stimulate glucose-dependent insulin secretion and suppress glucagon—lowering blood sugar without the hypoglycemia risk of insulin or sulfonylureas.

Renal-independent elimination

Unlike other DPP-4 inhibitors that are excreted through the kidneys and require dose adjustment as kidney function declines, Linagliptin is eliminated via the biliary and fecal route—making it uniquely safe to use at standard doses in patients with chronic kidney disease.

Weight-neutral tolerability

Does not cause weight gain and carries a low risk of hypoglycemia when used without insulin or sulfonylureas—offering well-tolerated blood sugar control that can be added to most existing diabetes regimens.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

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Frequently Asked Questions

How is Tradjenta different from other DPP-4 inhibitors like Januvia?

Tradjenta is eliminated primarily through bile and feces rather than the kidneys — meaning its dose doesn't need to be adjusted as kidney function declines. This makes it uniquely suitable for patients with moderate to severe chronic kidney disease.

Does Tradjenta cause low blood sugar?

Tradjenta alone has a low risk of hypoglycemia because it works through incretin hormones that only stimulate insulin when blood sugar is elevated. Risk increases when combined with insulin or sulfonylureas.

How quickly does Tradjenta lower blood sugar?

The full glucose-lowering effect at a given dose typically develops over 4–8 weeks of consistent once-daily use. Your clinician will assess A1C response at follow-up to determine whether the current dose is adequate.

What side effects might I experience?

Nasopharyngitis (cold-like symptoms), cough, and hypersensitivity reactions are the most commonly reported. Joint pain has been reported with DPP-4 inhibitors. Pancreatitis has been reported rarely — seek care for severe persistent abdominal pain.

Can Tradjenta be used in older adults with kidney disease?

Yes — its kidney-independent elimination makes it one of the preferred diabetes medications in older adults and those with declining kidney function, where many other diabetes drugs require dose adjustment or are contraindicated.
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