Tradjenta

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What is Tradjenta?

Tradjenta is a DPP-4 inhibitor used to improve blood sugar control in adults with Type 2 diabetes. It works by blocking the enzyme that rapidly breaks down incretin hormones GLP-1 and GIP, allowing these natural hormones to remain active longer and stimulate insulin release in a glucose-dependent way. A distinguishing feature of Tradjenta is that it's primarily eliminated through the bile and feces rather than the kidneys—making it the only DPP-4 inhibitor that doesn't require dose adjustment in patients with kidney disease. It's taken as a once-daily tablet and is weight-neutral with a low risk of hypoglycemia.

DPP-4 enzyme inhibition

Blocks dipeptidyl peptidase-4, extending the activity of GLP-1 and GIP incretin hormones that stimulate glucose-dependent insulin secretion and suppress glucagon—lowering blood sugar without the hypoglycemia risk of insulin or sulfonylureas.

Renal-independent elimination

Unlike other DPP-4 inhibitors that are excreted through the kidneys and require dose adjustment as kidney function declines, Tradjenta is eliminated via the biliary and fecal route—making it uniquely safe to use at standard doses in patients with chronic kidney disease.

Weight-neutral tolerability

Does not cause weight gain and carries a low risk of hypoglycemia when used without insulin or sulfonylureas—offering well-tolerated blood sugar control that can be added to most existing diabetes regimens.

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Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

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