Tizanidine

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What is Tizanidine?

Tizanidine is a short-acting muscle relaxant prescribed to treat spasticity—the muscle stiffness, spasms, and increased muscle tone associated with conditions like multiple sclerosis and spinal cord injury. It works in the spinal cord by activating alpha-2 adrenergic receptors, which reduces the release of excitatory neurotransmitters that drive muscle overactivity. Because its effects last only 3–6 hours, it's typically timed to provide relief during specific activities like physical therapy or sleep. It causes significant sedation and blood pressure lowering, so doses are carefully titrated.

Alpha-2 adrenergic agonism

Activates alpha-2 receptors in the spinal cord, reducing the release of excitatory amino acids like glutamate and aspartate that drive the hyperreflexia and excessive muscle tone behind spasticity.

Short-acting targeted relief

Its 3–6 hour duration allows dosing to be timed strategically—providing muscle relaxation during specific periods of activity, therapy, or rest without continuous sedation throughout the day.

Spinal cord and MS spasticity

Particularly effective for the neurologically driven spasticity of multiple sclerosis and spinal cord injury, where overactive spinal reflex arcs cause painful, disabling muscle stiffness and involuntary spasms.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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