Sucralfate

Generic for Carafate

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What is Sucralfate?

Sucralfate is a prescription medication used to treat and prevent duodenal ulcers by forming a protective coating over the ulcer site rather than reducing stomach acid. When it comes into contact with the acidic environment of the stomach, it becomes a sticky, paste-like substance that adheres selectively to ulcerated tissue—creating a physical barrier that shields the wound from acid, pepsin, and bile while healing takes place. It's taken on an empty stomach, 1 hour before meals and at bedtime, and is particularly valued as a non-systemic option that works locally without significant absorption into the bloodstream.

Ulcer-selective protective barrier

In the acidic stomach environment, Sucralfate polymerizes into a viscous gel that binds preferentially to damaged mucosal tissue—forming a physical shield over the ulcer that protects it from further acid and pepsin injury during healing.

Non-acid-suppressing mechanism

Works independently of acid production—rather than reducing stomach acid like PPIs or H2 blockers, Sucralfate protects the ulcer from the acid that's already present, offering a complementary approach to ulcer management.

Minimal systemic absorption

Less than 5% of Sucralfate is absorbed into the bloodstream, meaning its protective action is almost entirely local—making it safe for patients who need to avoid systemic medications or who have concerns about drug interactions.

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