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Spironolactone (Aldactone)
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Spironolactone (Aldactone)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Spironolactone (Aldactone) or a refill of an existing one.

Licensed providers in all 50 states

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Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

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Available nationwide

What is Spironolactone (Aldactone)?

Spironolactone is a potassium-sparing diuretic with antiandrogen properties, giving it a uniquely broad range of uses. It's prescribed for heart failure, high blood pressure, fluid retention from liver or kidney disease, and primary hyperaldosteronism. It's also widely used off-label for hormonal acne, female pattern hair loss, and hirsutism in women—conditions driven by androgen excess. By blocking both aldosterone receptors in the kidney and androgen receptors in target tissues, it addresses both fluid balance and hormone-driven conditions with a single medication. It's taken once or twice daily.

Aldosterone receptor blockade

Blocks mineralocorticoid receptors in the kidney's collecting tubules, preventing aldosterone from promoting sodium retention and potassium excretion—reducing fluid volume and blood pressure while conserving potassium.

Antiandrogen activity

Blocks androgen receptors in skin and hair follicles, reducing the hormonal stimulation that drives excess oil production, acne, unwanted hair growth, and female pattern hair loss—explaining its widespread off-label use in women.

Heart failure benefit

At appropriate doses, Spironolactone reduces mortality and hospitalizations in heart failure with reduced ejection fraction by blocking the harmful effects of excess aldosterone on the heart and blood vessels—a disease-modifying benefit beyond simple diuresis.

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Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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Frequently Asked Questions

What are the different reasons spironolactone might be prescribed?

Spironolactone is prescribed for heart failure, high blood pressure, fluid retention from liver or kidney disease, primary hyperaldosteronism, and — widely off-label — hormonal acne and female pattern hair loss in women.

How long before spironolactone helps with acne?

For hormonal acne, meaningful improvement typically takes 3–6 months of consistent daily use. Some people see earlier changes, but full results are usually not apparent until at least 3 months of treatment.

Why do I need to monitor my potassium on spironolactone?

Spironolactone is a potassium-sparing diuretic — it can raise potassium levels. High potassium (hyperkalemia) can cause serious heart rhythm problems. Avoiding high-potassium foods and salt substitutes and periodic blood monitoring are important.

What side effects might I experience?

Increased urination, dizziness, breast tenderness or enlargement, menstrual irregularities, and elevated potassium are the most commonly reported effects. Spironolactone is not recommended during pregnancy due to hormonal effects on a male fetus.

Is spironolactone safe for use in heart failure long-term?

Yes — at appropriate doses with regular monitoring, spironolactone has proven mortality and hospitalization benefits in heart failure with reduced ejection fraction. Long-term use with kidney function and potassium monitoring is standard of care.
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