Skyrizi

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What is Skyrizi?

Skyrizi is a biologic injectable medication used to treat moderate-to-severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It works by specifically targeting interleukin-23 (IL-23), a protein that plays a central role in driving the chronic inflammation responsible for these conditions. By blocking IL-23, Skyrizi interrupts the inflammatory cascade upstream—before it triggers the immune cells that cause skin plaques, joint inflammation, and intestinal damage. For psoriasis, it's given as two injections at week 0 and 4, then every 12 weeks.

Selective IL-23 inhibition

Binds to the p19 subunit of IL-23, blocking this cytokine's ability to activate Th17 immune cells—the primary drivers of the chronic skin, joint, and intestinal inflammation in its approved indications.

Upstream pathway blockade

By targeting IL-23 before it triggers downstream inflammatory cascades, Skyrizi interrupts the inflammation earlier and more completely than treatments that block end-stage cytokines like IL-17.

High and durable response rates

Clinical trials show that a large proportion of plaque psoriasis patients achieve clear or almost clear skin—with response rates that hold up or improve over time with the every-12-week maintenance dosing schedule.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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