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Simbrinza (Brimonidine - brinzolamide)
Virtual visit

Simbrinza (Brimonidine - brinzolamide)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Simbrinza (Brimonidine - brinzolamide) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Simbrinza?

Simbrinza is a prescription eye drop combining two intraocular pressure-lowering medications—brimonidine (an alpha-2 agonist) and brinzolamide (a carbonic anhydrase inhibitor)—in a single drop for patients with open-angle glaucoma or ocular hypertension. Each ingredient lowers IOP through a different mechanism, and their combination provides additive pressure reduction compared to either drug used alone. By pairing two complementary mechanisms in one drop, Simbrinza reduces the number of separate eye drops patients need to manage, improving convenience and adherence. It's applied three times daily.

Dual complementary IOP reduction

Brimonidine reduces aqueous humor production and increases uveoscleral outflow via alpha-2 receptor activation, while brinzolamide inhibits carbonic anhydrase to reduce aqueous secretion through a separate pathway—providing additive pressure lowering.

Alpha-2 agonist component

Brimonidine activates alpha-2 adrenergic receptors in the ciliary body, suppressing aqueous humor production while also increasing the alternative uveoscleral drainage route to further lower intraocular pressure.

Simplified glaucoma regimen

Combining two different drug classes in one drop reduces the total number of eye drop bottles and instillations needed each day—improving adherence in patients already managing multiple glaucoma medications.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

What is Simbrinza used for?

Simbrinza is a prescription eye drop combining two glaucoma medications — brimonidine and brinzolamide — to lower intraocular pressure in open-angle glaucoma or ocular hypertension when a single drop isn't providing enough control.

How many times a day do I need to use Simbrinza?

Simbrinza is applied three times daily — morning, midday, and evening. Consistent spacing throughout the day helps maintain steady intraocular pressure reduction.

Can I use Simbrinza alongside other glaucoma drops?

Simbrinza is designed as an add-on when a single agent is insufficient. If using other eye drops, wait at least 5–10 minutes between applying different drops to prevent dilution and ensure each medication is fully absorbed.

What side effects might I experience?

Blurred vision after instillation, stinging or burning, eye redness, drowsiness, and dry mouth are the most commonly reported effects. Brimonidine can cause drowsiness in some patients — note this if driving or operating machinery.

Is Simbrinza safe for patients with cardiovascular disease?

Brimonidine can affect heart rate and blood pressure in some patients. People with severe cardiovascular disease, depression, or Raynaud's phenomenon should discuss the appropriateness of brimonidine-containing drops with their clinician.
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