Simbrinza

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Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Simbrinza?

Simbrinza is a prescription eye drop combining two intraocular pressure-lowering medications—brimonidine (an alpha-2 agonist) and brinzolamide (a carbonic anhydrase inhibitor)—in a single drop for patients with open-angle glaucoma or ocular hypertension. Each ingredient lowers IOP through a different mechanism, and their combination provides additive pressure reduction compared to either drug used alone. By pairing two complementary mechanisms in one drop, Simbrinza reduces the number of separate eye drops patients need to manage, improving convenience and adherence. It's applied three times daily.

Dual complementary IOP reduction

Brimonidine reduces aqueous humor production and increases uveoscleral outflow via alpha-2 receptor activation, while brinzolamide inhibits carbonic anhydrase to reduce aqueous secretion through a separate pathway—providing additive pressure lowering.

Alpha-2 agonist component

Brimonidine activates alpha-2 adrenergic receptors in the ciliary body, suppressing aqueous humor production while also increasing the alternative uveoscleral drainage route to further lower intraocular pressure.

Simplified glaucoma regimen

Combining two different drug classes in one drop reduces the total number of eye drop bottles and instillations needed each day—improving adherence in patients already managing multiple glaucoma medications.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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—Kaylee, Louisiana

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—Nika, Tennessee

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