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Silvadene (Silver sulfadiazine)
Virtual visit

Silvadene (Silver sulfadiazine)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Silvadene (Silver sulfadiazine) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Silvadene (Silver sulfadiazine)?

Silvadene is a prescription topical antimicrobial cream used to prevent and treat bacterial and fungal infections in patients with second and third degree burns. It combines the antimicrobial properties of silver with the antibiotic activity of sulfadiazine, providing broad-spectrum coverage against the wide range of organisms that can colonize burn wounds. Applied directly to the burn surface and covered with a dressing once or twice daily, it helps keep the wound clean and infection-free during the critical healing period. It also provides a moist wound environment that supports tissue healing.

Dual silver and sulfonamide antimicrobial action

Silver ions disrupt bacterial cell membrane function and inhibit enzyme activity through multiple simultaneous mechanisms, while sulfadiazine blocks folate synthesis—providing broad-spectrum antibacterial and antifungal coverage across the diverse pathogens that threaten burn wounds.

Broad burn wound coverage

Effective against gram-positive bacteria, gram-negative bacteria including Pseudomonas aeruginosa, and Candida yeast—addressing the full spectrum of organisms that colonize and infect serious burns during the vulnerable healing period.

Moist wound environment support

The cream base maintains appropriate wound moisture that supports epithelialization and healing, while the antimicrobial activity protects against the infection that is the primary cause of morbidity in serious burn patients.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

What is Silvadene used for?

Silvadene is a prescription antimicrobial cream applied to second and third degree burns to prevent and treat bacterial and fungal infections during the healing process — one of the standard burn wound care treatments.

How often is Silvadene applied?

Silvadene is typically applied once or twice daily after the wound is gently cleaned. The wound is then covered with a sterile dressing. Your clinician or wound care team will specify the frequency for your situation.

Why does Silvadene turn the wound black?

A dark-colored pseudoeschar can form as Silvadene reacts with wound exudate. This is normal and not a sign of infection or necrosis — it's removed during wound cleaning before each fresh application.

What side effects might I experience?

Local burning, itching, and redness at the application site are common. Leukopenia — a reduction in white blood cells — has been reported with extensive use. Sulfa allergy is a contraindication to using Silvadene.

Is Silvadene safe if I have a sulfa allergy?

No. Silvadene contains sulfadiazine — a sulfonamide antibiotic. It should not be used in patients with known sulfa allergies. Always inform your treatment team of any drug allergies before burn wound treatment.
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