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Questran (cholestyramine)
Virtual visit

Questran (cholestyramine)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Questran (cholestyramine) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Questran (cholestyramine)?

Questran is a bile acid sequestrant used to lower LDL cholesterol and to treat itching caused by bile acid accumulation in liver disease. It works in the intestine by binding to bile acids—which are made from cholesterol—and preventing them from being reabsorbed. The body then has to draw on cholesterol stores to make new bile acids, reducing circulating LDL levels. It's taken as a powder mixed with water or juice, one to six times daily depending on the dose, and doesn't enter the bloodstream—making it one of the safest cholesterol medications for certain populations, including pregnant women.

Bile acid sequestration

Binds bile acids in the intestinal lumen and prevents their reabsorption into the enterohepatic circulation, forcing the liver to synthesize new bile acids from circulating cholesterol—thereby reducing LDL cholesterol levels.

Non-systemic mechanism

Cholestyramine is not absorbed into the bloodstream and works entirely within the GI tract—making it one of the few cholesterol-lowering medications considered safe during pregnancy and for patients who cannot tolerate systemic drugs.

Cholestatic itch relief

In liver disease where bile acids accumulate in the skin and cause intense itching, Questran reduces circulating bile acid levels by interrupting their intestinal recycling—providing meaningful relief from cholestasis-related pruritus.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How do I take Questran powder?

Mix the powder thoroughly in 4–6 ounces of water, juice, or another non-carbonated beverage until fully dissolved. Take it with meals. Never take it dry — the undissolved powder can cause choking or esophageal irritation.

How long before Questran lowers my cholesterol?

LDL-lowering effects are typically measurable within 4–6 weeks. Your clinician will check a lipid panel to assess response and determine whether dose adjustment or additional therapy is needed.

Why does Questran cause constipation?

Cholestyramine binds bile acids in the intestine and also has constipating properties. Increasing fluid intake, dietary fiber, and physical activity helps significantly. Your clinician may recommend a stool softener if needed.

What side effects might I experience?

Constipation, bloating, gas, nausea, and stomach discomfort are the most common — particularly when starting. These often improve after the first few weeks. High doses may also reduce absorption of fat-soluble vitamins A, D, E, and K.

Does Questran interact with other medications?

Yes — significantly. Questran can bind other oral medications and reduce their absorption. Take all other medications at least 1 hour before or 4–6 hours after Questran. This includes statins, thyroid medication, and warfarin.
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