Promethazine

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What is Promethazine?

Promethazine is a phenothiazine antihistamine used to treat nausea, vomiting, motion sickness, and allergic reactions. It works by blocking histamine and dopamine receptors in the brain, particularly in the area that triggers the vomiting reflex. It also has sedating properties that make it useful for managing anxiety before medical procedures or for promoting sleep in certain situations. Available in tablet, suppository, and injectable form, it's a versatile medication that's been used in clinical practice for decades.

Dual receptor blockade

Blocks both histamine H1 receptors and dopamine receptors in the chemoreceptor trigger zone of the brain—directly suppressing the signals that initiate the nausea and vomiting response.

Motion sickness and allergy relief

Its antihistamine activity makes it effective for motion-related nausea and allergic symptoms like itching, runny nose, and hives by preventing histamine from binding to its receptors.

Sedating properties

Promethazine's CNS effects produce meaningful sedation, making it useful for pre-procedure anxiety relief and as a sleep aid in appropriate clinical settings.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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