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Periogard (chlorhexidine gluconate)
Virtual visit

Periogard (chlorhexidine gluconate)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Periogard (chlorhexidine gluconate) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Periogard (chlorhexidine gluconate)?

Periogard is a prescription antiseptic oral rinse containing chlorhexidine gluconate, used to treat gingivitis—inflammation of the gums caused by bacterial plaque. It's typically prescribed following dental procedures or for patients with significant gum disease to reduce the bacterial load in the mouth and allow gum tissue to heal. Chlorhexidine works by disrupting bacterial cell membranes, killing the bacteria responsible for plaque and gum inflammation. It's used twice daily as a rinse for 30 seconds—not swallowed—and may cause temporary tooth staining and altered taste with extended use.

Bacterial membrane disruption

Chlorhexidine binds to negatively charged bacterial cell walls and membranes, disrupting their integrity and causing bacterial cell death—reducing the plaque-forming bacteria responsible for gingivitis.

Substantivity advantage

Chlorhexidine adheres to oral tissues and continues releasing antibacterial activity for hours after rinsing—a property called substantivity—providing longer-lasting bacterial suppression than standard antiseptic rinses.

Post-procedural gum healing

By significantly reducing oral bacterial burden, Periogard creates a cleaner environment for gum tissue to heal after dental procedures or during treatment of periodontitis—complementing mechanical cleaning and professional dental care.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How do I use Periogard correctly?

Rinse with 15 ml (half an ounce) for 30 seconds twice daily — after brushing. Spit it out completely; do not swallow. Do not eat, drink, or rinse your mouth with water for at least 30 minutes after use.

Will Periogard stain my teeth?

Yes — tooth staining and tongue discoloration are well-known effects of chlorhexidine use, particularly with longer courses. Professional cleaning typically removes the staining. Avoiding coffee, tea, and red wine helps minimize discoloration.

How long do I need to use Periogard?

Most courses prescribed for gingivitis or post-dental procedure care last 4–6 weeks. Prolonged use beyond what's prescribed can disrupt normal oral bacteria balance — use it only as directed by your clinician.

What side effects might I experience?

Tooth and tongue staining, altered taste perception, mouth irritation, and dry mouth are the most commonly reported effects. These are generally mild and reversible after completing treatment.

Does Periogard replace brushing and flossing?

No. Periogard is an adjunct to — not a replacement for — regular brushing, flossing, and professional dental care. It significantly reduces bacterial load in the mouth but cannot substitute for mechanical plaque removal.
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