Otezla

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What is Otezla?

Otezla is a prescription oral medication used to treat moderate to severe plaque psoriasis, active psoriatic arthritis, and oral ulcers associated with Behçet's disease. Unlike biologic medications that require injection, Otezla is taken as a pill twice daily and works by inhibiting PDE4—an enzyme inside immune cells that regulates the production of inflammatory cytokines. By blocking PDE4, it raises cyclic AMP levels and dampens the inflammatory signaling that drives skin plaques and joint inflammation. It doesn't require blood monitoring and has a straightforward titration schedule over the first week to minimize GI side effects.

PDE4 inhibition

Blocks phosphodiesterase 4 inside immune cells, elevating cyclic AMP and dampening the overproduction of pro-inflammatory cytokines—TNF-alpha, IL-17, IL-23—that drive the chronic skin and joint inflammation of psoriasis and psoriatic arthritis.

Oral non-biologic mechanism

Provides targeted anti-inflammatory activity at the intracellular level through an oral pill rather than injectable biologic therapy—offering meaningful disease control without the immunosuppression depth and monitoring requirements of systemic biologics.

No monitoring or refrigeration required

Unlike many psoriasis biologics that require regular blood tests and cold storage, Otezla requires no lab monitoring and is stored at room temperature—simplifying the treatment experience for patients managing chronic disease long-term.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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