Opzelura

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Available nationwide

What is Opzelura?

Opzelura is a prescription topical cream containing Opzelura, a JAK inhibitor used to treat atopic dermatitis (eczema) and vitiligo. It works by blocking JAK1 and JAK2 enzymes that drive the inflammatory and immune signaling responsible for these skin conditions. For eczema, it reduces the itch, redness, and inflammation of flares. For vitiligo, it helps repigment areas of skin that have lost their color due to immune destruction of melanocytes. It's applied twice daily to affected areas and represents a targeted, mechanism-specific approach to inflammatory skin disease.

JAK1/JAK2 inhibition

Blocks Janus kinase enzymes that transmit inflammatory cytokine signals within skin cells, interrupting the immune-driven inflammation and immune cell activation that cause both eczema flares and vitiligo depigmentation.

Itch and inflammation relief

By dampening the JAK-STAT signaling pathway in the skin, Opzelura rapidly reduces the intense itch, redness, and skin barrier disruption characteristic of atopic dermatitis flares.

Vitiligo repigmentation

For vitiligo, JAK inhibition helps reverse the immune attack on melanocytes and allows pigment-producing cells to recover and repopulate depigmented patches—a mechanism distinct from any previously available vitiligo treatment.

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Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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