Ondansetron (Zofran)

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Available nationwide

What is Ondansetron?

Ondansetron is a powerful anti-nausea medication prescribed to prevent and treat nausea and vomiting caused by chemotherapy, radiation, surgery, and in some cases severe morning sickness during pregnancy. It works by blocking serotonin receptors in both the gut and the brain that trigger the vomiting reflex. Unlike older anti-nausea medications that tend to cause heavy sedation, Ondansetron is well-tolerated and allows most people to function normally while taking it. It's available as a tablet, orally dissolving tablet, or injectable form.

Serotonin (5-HT3) receptor blockade

Blocks 5-HT3 receptors in the gastrointestinal tract and the brain's vomiting center, preventing the serotonin surge that chemotherapy and other triggers use to initiate the nausea and vomiting response.

Minimal sedation

Unlike antihistamine or dopamine-blocking antiemetics, Ondansetron provides strong nausea control without the heavy sedation or cognitive impairment that makes many anti-nausea medications difficult to tolerate.

Versatile delivery

Available in multiple formats—including an orally dissolving tablet that works even when swallowing is difficult due to nausea—making it practical across a wide range of clinical situations.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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