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Nucala (Mepolizumab)
Virtual visit

Nucala (Mepolizumab)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Nucala (Mepolizumab) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Nucala (Mepolizumab)?

Nucala is a biologic injection used as an add-on maintenance treatment for severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome. It works by targeting interleukin-5 (IL-5)—the cytokine primarily responsible for the growth, activation, and survival of eosinophils, the white blood cells that drive eosinophilic inflammation. By blocking IL-5, Nucala dramatically reduces circulating and tissue eosinophil counts, decreasing the underlying inflammation that causes severe asthma attacks and organ damage in eosinophilic conditions. It's given as a subcutaneous injection once every four weeks.

IL-5 cytokine blockade

Binds to and neutralizes interleukin-5, the primary growth and survival factor for eosinophils—preventing IL-5 from binding to its receptor on eosinophil progenitors and mature cells, dramatically reducing eosinophil production and survival.

Eosinophil count reduction

Clinical trials showed reductions in blood eosinophil counts of greater than 80% with Nucala—directly reducing the tissue eosinophilia responsible for airway inflammation in severe asthma and organ involvement in EGPA.

Asthma exacerbation prevention

By controlling the eosinophilic inflammation driving severe asthma, Nucala significantly reduces the frequency of severe asthma attacks and the need for oral corticosteroid rescue courses—improving quality of life and reducing long-term steroid burden.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

What is Nucala used for?

Nucala is approved for severe eosinophilic asthma (as add-on maintenance), eosinophilic granulomatosis with polyangiitis (EGPA), and hypereosinophilic syndrome — conditions where abnormally high eosinophil counts drive inflammation and organ damage.

How long before Nucala reduces my asthma attacks?

Clinical trials showed meaningful reductions in exacerbation rates within the first 6 months. Many patients also experience progressive reduction in oral steroid requirements — an important quality-of-life benefit tracked over time.

How is Nucala given?

Nucala is injected subcutaneously once every 4 weeks — at a clinic, healthcare provider's office, or at home after proper training. The 100 mg dose is standard for asthma; EGPA uses a different dosing protocol.

What side effects might I experience?

Headache, back pain, fatigue, injection site reactions, and upper respiratory infections are the most commonly reported effects. Herpes zoster (shingles) reactivation has been reported — vaccination before starting is worth discussing.

Will Nucala replace my other asthma medications?

No — Nucala is an add-on therapy used alongside existing controller and rescue medications, not a replacement for them. Over time, your clinician may be able to reduce oral corticosteroid doses if eosinophil levels and symptoms improve.
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