Nocdurna

Brand for Desmopressin

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Most insurance accepted

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Available nationwide

What is Nocdurna?

Nocdurna is a low-dose sublingual Nocdurna tablet specifically formulated to treat nocturia—waking up one or more times during the night to urinate—due to nocturnal polyuria (producing too much urine at night). It works by mimicking ADH (antidiuretic hormone), the natural hormone that signals the kidneys to concentrate urine and reduce urine output during sleep. Nocdurna comes in sex-specific doses—a lower dose for women and a higher dose for men—reflecting differences in how the drug is metabolized. It's placed under the tongue at least one hour before bed.

ADH receptor activation

Binds to V2 receptors in the kidney collecting ducts, mimicking the natural antidiuretic hormone signal that causes the kidneys to reabsorb water and concentrate urine—reducing nighttime urine production.

Nocturnal polyuria targeting

Specifically addresses the nighttime overproduction of urine that disrupts sleep, rather than treating overall bladder capacity or urgency—making it distinct from other overactive bladder medications.

Sex-differentiated dosing

Available in separate formulations for men and women based on pharmacokinetic differences—women are prescribed a lower dose due to slower clearance, which reduces the risk of hyponatremia (low sodium) that can occur with excessive Nocdurna activity.

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Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

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