General
Nizoral (ketoconazole) Shampoo (Rx Strength)
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Nizoral (ketoconazole) Shampoo (Rx Strength)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Nizoral (ketoconazole) Shampoo (Rx Strength) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Nizoral Shampoo (Rx Strength)?

Prescription-strength Nizoral is a 2% ketoconazole antifungal shampoo used to treat seborrheic dermatitis and dandruff caused by Malassezia yeast on the scalp. At prescription concentration, it's more potent than the 1% OTC version and is used for more persistent or severe cases. Ketoconazole works by disrupting the fungal cell membrane, killing the yeast responsible for flaking, scaling, and scalp irritation. It's typically used twice weekly for a few weeks, then as needed for ongoing control.

Ergosterol synthesis inhibition

Blocks the fungal CYP51 enzyme, disrupting ergosterol production in Malassezia yeast cell membranes—causing membrane instability and fungal cell death directly on the scalp surface.

Higher-concentration antifungal activity

The 2% prescription formulation delivers greater antifungal potency than OTC options, providing more effective control of persistent seborrheic dermatitis and dandruff that hasn't responded to lower-strength treatments.

Scalp inflammation reduction

Beyond killing the yeast, ketoconazole has direct anti-inflammatory properties that help reduce the scalp redness, itching, and irritation that accompany fungal overgrowth—addressing both the cause and the inflammatory response.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

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Frequently Asked Questions

How is prescription Nizoral different from the OTC version?

Prescription Nizoral contains 2% ketoconazole — twice the concentration of the 1% OTC version. It's prescribed for more persistent or severe seborrheic dermatitis and dandruff that haven't responded to lower-strength antifungal shampoos.

How often should I use prescription Nizoral shampoo?

Typically used twice weekly for 4 weeks during active treatment. A maintenance schedule of once every 1–2 weeks may be recommended afterward to keep seborrheic dermatitis under long-term control.

How long do I leave it on before rinsing?

Lather into the scalp and leave for 3–5 minutes before rinsing. This contact time is important — rinsing immediately after application significantly reduces antifungal effectiveness.

What side effects might I experience?

Scalp irritation, dryness, oiliness, and temporary changes in hair texture are most commonly reported. Contact your clinician if you experience significant burning, severe itching, or rash after application.

Can I use Nizoral on color-treated hair?

Exercise caution. Ketoconazole shampoo can affect hair color or texture in some cases. Discuss with your clinician if you have color-treated, bleached, or chemically processed hair before starting treatment.
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