Nitrostat

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What is Nitrostat?

Nitrostat is a fast-acting sublingual nitroglycerin tablet used to provide rapid relief of acute angina attacks—the chest pain that occurs when the heart muscle doesn't get enough oxygen-rich blood. It's placed under the tongue where it dissolves and absorbs quickly into the bloodstream, beginning to work within 1–3 minutes. Nitroglycerin works by relaxing and widening both the coronary arteries and the veins returning blood to the heart, reducing cardiac workload and improving blood flow to the heart muscle. It can also be taken just before activities known to trigger angina.

Nitric oxide-mediated vasodilation

Nitroglycerin is converted to nitric oxide in vascular smooth muscle, activating guanylate cyclase and causing both venous and arterial relaxation—reducing preload, afterload, and myocardial oxygen demand while improving coronary blood flow.

Sublingual rapid onset

Dissolving under the tongue delivers nitroglycerin directly into the sublingual veins for rapid systemic absorption, bypassing first-pass liver metabolism and providing onset of action within 1–3 minutes—essential for acute angina relief.

Rescue and prophylactic use

Used both to treat angina attacks as they occur and to prevent them when taken 5–10 minutes before activities known to trigger symptoms—providing flexible, on-demand cardiovascular protection.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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