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Nitrostat (nitroglycerin sublingual)
Virtual visit

Nitrostat (nitroglycerin sublingual)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Nitrostat (nitroglycerin sublingual) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Nitrostat (nitroglycerin sublingual)?

Nitrostat is a fast-acting sublingual nitroglycerin tablet used to provide rapid relief of acute angina attacks—the chest pain that occurs when the heart muscle doesn't get enough oxygen-rich blood. It's placed under the tongue where it dissolves and absorbs quickly into the bloodstream, beginning to work within 1–3 minutes. Nitroglycerin works by relaxing and widening both the coronary arteries and the veins returning blood to the heart, reducing cardiac workload and improving blood flow to the heart muscle. It can also be taken just before activities known to trigger angina.

Nitric oxide-mediated vasodilation

Nitroglycerin is converted to nitric oxide in vascular smooth muscle, activating guanylate cyclase and causing both venous and arterial relaxation—reducing preload, afterload, and myocardial oxygen demand while improving coronary blood flow.

Sublingual rapid onset

Dissolving under the tongue delivers nitroglycerin directly into the sublingual veins for rapid systemic absorption, bypassing first-pass liver metabolism and providing onset of action within 1–3 minutes—essential for acute angina relief.

Rescue and prophylactic use

Used both to treat angina attacks as they occur and to prevent them when taken 5–10 minutes before activities known to trigger symptoms—providing flexible, on-demand cardiovascular protection.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How do I use Nitrostat correctly during a chest pain episode?

Place one tablet under the tongue and let it dissolve — do not swallow it. Sit or lie down. If pain doesn't improve after 5 minutes, take a second tablet. After a third tablet at 5-minute intervals, call 911 immediately.

Why must I sit or lie down when taking Nitrostat?

Nitroglycerin causes rapid vasodilation that can significantly lower blood pressure — standing suddenly after taking it can cause dizziness or fainting. Sitting or lying down prevents dangerous falls.

How should I store Nitrostat?

Store in the original amber glass container away from heat, light, and moisture. Do not transfer to plastic containers — nitroglycerin degrades quickly when exposed to air, heat, or light. Replace every 6 months or at expiration.

What side effects might I experience?

Throbbing headache, flushing, dizziness, and a burning or tingling sensation under the tongue are common and expected — the headache confirms the medication is working. These effects are usually brief and resolve within minutes.

Can I take Nitrostat if I use erectile dysfunction medications?

No. Combining nitroglycerin with PDE5 inhibitors (Viagra, Cialis, Levitra, Stendra) can cause a severe and potentially life-threatening drop in blood pressure. This combination is absolutely contraindicated — always inform any treating clinician.
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