Neffy

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What is Neffy?

Neffy is a prescription epinephrine nasal spray used for the emergency treatment of severe allergic reactions (anaphylaxis) including those triggered by insect stings, foods, medications, or unknown causes. It delivers epinephrine intranasally, providing a needle-free alternative to the EpiPen auto-injector. When anaphylaxis causes airways to swell shut and blood pressure to drop, Neffy rapidly reverses these life-threatening responses. It's designed for patients who may hesitate to use an auto-injector and for those who find a nasal spray more accessible in an emergency. Like all epinephrine emergency treatments, it's a bridge to emergency medical care—not a substitute for calling 911.

Intranasal epinephrine delivery

Delivers a precise dose of epinephrine through the nasal mucosa directly into the bloodstream, bypassing the need for injection while achieving systemic drug levels fast enough to reverse anaphylaxis—the first FDA-approved needle-free epinephrine treatment for severe allergic reactions.

Rapid anaphylaxis reversal

Epinephrine causes immediate vasoconstriction, raises blood pressure, relaxes airway smooth muscle, and reduces vascular permeability—reversing the simultaneous cardiovascular and airway collapse that makes anaphylaxis life-threatening within minutes.

Needle-free accessibility

Designed to reduce the barrier to emergency epinephrine use—eliminating needle anxiety and the training required to use an auto-injector—while maintaining the speed and effectiveness needed to treat anaphylaxis before emergency responders arrive.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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