General
Neffy
Virtual visit

Neffy

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Neffy or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Neffy?

Neffy is a prescription epinephrine nasal spray used for the emergency treatment of severe allergic reactions (anaphylaxis) including those triggered by insect stings, foods, medications, or unknown causes. It delivers epinephrine intranasally, providing a needle-free alternative to the EpiPen auto-injector. When anaphylaxis causes airways to swell shut and blood pressure to drop, Neffy rapidly reverses these life-threatening responses. It's designed for patients who may hesitate to use an auto-injector and for those who find a nasal spray more accessible in an emergency. Like all epinephrine emergency treatments, it's a bridge to emergency medical care—not a substitute for calling 911.

Intranasal epinephrine delivery

Delivers a precise dose of epinephrine through the nasal mucosa directly into the bloodstream, bypassing the need for injection while achieving systemic drug levels fast enough to reverse anaphylaxis—the first FDA-approved needle-free epinephrine treatment for severe allergic reactions.

Rapid anaphylaxis reversal

Epinephrine causes immediate vasoconstriction, raises blood pressure, relaxes airway smooth muscle, and reduces vascular permeability—reversing the simultaneous cardiovascular and airway collapse that makes anaphylaxis life-threatening within minutes.

Needle-free accessibility

Designed to reduce the barrier to emergency epinephrine use—eliminating needle anxiety and the training required to use an auto-injector—while maintaining the speed and effectiveness needed to treat anaphylaxis before emergency responders arrive.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

What is Neffy and how is it used?

Neffy is a prescription epinephrine nasal spray — the first needle-free option for treating anaphylaxis. It's sprayed into one nostril at the first signs of a severe allergic reaction, followed by calling 911 for emergency care.

How does Neffy compare to the EpiPen?

Both deliver epinephrine for anaphylaxis — EpiPen by injection, Neffy by nasal spray. Neffy eliminates the needle, which may reduce hesitation during an emergency for people with needle anxiety or those who find the auto-injector intimidating.

Does Neffy work as quickly as an epinephrine injection?

Absorption through the nasal mucosa is somewhat slower than subcutaneous injection, but Neffy has been shown to achieve adequate epinephrine levels to treat anaphylaxis. In emergencies, the ease of use may compensate for any timing difference.

What side effects might I experience from Neffy?

Racing heart, shakiness, anxiety, pallor, and headache are expected effects of epinephrine — they reflect the medication working. Nasal irritation at the application site may also occur. These effects are brief and far preferable to anaphylaxis.

Should I still call 911 after using Neffy?

Yes — always. Anaphylaxis can return after epinephrine wears off (biphasic reaction), and emergency medical evaluation is required after every anaphylactic episode regardless of how well Neffy worked initially.
Logo

© 2026 Path Healthcare Systems Corp.