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Monopril HCT (Fosinopril - hydrochlorothiazide)
Virtual visit

Monopril HCT (Fosinopril - hydrochlorothiazide)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Monopril HCT (Fosinopril - hydrochlorothiazide) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Monopril HCT (Fosinopril - hydrochlorothiazide)?

Monopril HCT is a combination blood pressure medication pairing fosinopril, an ACE inhibitor, with hydrochlorothiazide (HCTZ), a thiazide diuretic. Fosinopril reduces blood pressure by blocking the enzyme that produces angiotensin II—a potent vasoconstrictor—while HCTZ lowers blood pressure by increasing renal excretion of salt and water to reduce blood volume. The two mechanisms work synergistically, and their combination produces greater blood pressure reduction than either alone. Fosinopril is notably excreted through both the kidneys and liver, making it a useful option for patients with mild-to-moderate kidney impairment. It's taken once daily.

ACE inhibition and diuresis combination

Fosinopril blocks angiotensin-converting enzyme, preventing angiotensin II production and causing vasodilation, while HCTZ reduces circulating fluid volume through renal sodium excretion—two complementary and additive blood pressure-lowering mechanisms in a single tablet.

Dual elimination pathway advantage

Fosinopril is unique among ACE inhibitors in being eliminated through both renal and hepatic routes, making dose adjustment less critical as kidney function declines—a practical advantage for hypertensive patients with comorbid kidney disease.

Electrolyte balance considerations

ACE inhibitors tend to retain potassium while thiazide diuretics waste it—the combination partially offsets this risk, though electrolyte monitoring remains important, particularly in patients with kidney disease or on other medications affecting potassium.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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Frequently Asked Questions

Why are two blood pressure medications combined in Monopril HCT?

Combining fosinopril (an ACE inhibitor) and hydrochlorothiazide (a diuretic) in one tablet targets blood pressure through two complementary mechanisms — greater reduction than either alone — while simplifying the daily regimen to a single pill.

What makes fosinopril different from other ACE inhibitors?

Fosinopril is eliminated through both the liver and kidneys — unlike most ACE inhibitors that rely primarily on renal excretion. This dual elimination pathway makes it more flexible for patients with mild-to-moderate kidney disease.

How long before Monopril HCT lowers my blood pressure?

Blood pressure reduction typically begins within the first week. Full effect at a given dose develops over 2–4 weeks. Your clinician may adjust the dose after an adequate trial period if blood pressure targets aren't met.

What side effects might I experience?

Dry cough from fosinopril, dizziness upon standing, increased urination, low potassium, and elevated uric acid from HCTZ are the most commonly reported effects. The cough is the most frequent reason patients switch from ACE inhibitors to ARBs.

Can I take Monopril HCT during pregnancy?

No. Fosinopril — like all ACE inhibitors — is contraindicated in pregnancy and can cause serious fetal harm. Stop taking it immediately and contact your clinician if pregnancy occurs.
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