Megestrol

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Most insurance accepted

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Available nationwide

What is Megestrol?

Megestrol is a synthetic progestin used primarily to stimulate appetite and promote weight gain in patients experiencing significant weight loss and anorexia associated with cancer, HIV/AIDS, or other serious illnesses. At the doses used for appetite stimulation, it works through hormonal and metabolic pathways that increase hunger and improve caloric intake. It's also used in some cases to treat certain hormone-sensitive breast and endometrial cancers. Available in tablet and oral suspension form, it's taken once or multiple times daily depending on the indication.

Appetite stimulation

At higher doses, Megestrol activates appetite-regulating pathways in the hypothalamus and may suppress pro-inflammatory cytokines like TNF-alpha and IL-6 that contribute to the anorexia and metabolic wasting seen in serious illness.

Weight and lean mass support

Promotes caloric intake and helps reverse unintentional weight loss in patients with cancer- or HIV-related cachexia—improving nutritional status, energy levels, and overall quality of life.

Hormonal anti-tumor activity

As a progestin, Megestrol can inhibit the growth of hormone receptor-positive breast and endometrial cancers by opposing estrogen's stimulating effects on tumor cell proliferation.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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