General MedicineGeneral Medicine
Malarone

Malarone

Brand for atovaquone

Without insurance

With insurance

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Malarone?

Malarone is a prescription antimalarial medication combining atovaquone and proguanil, used to both prevent and treat malaria caused by Plasmodium falciparum — the most dangerous malaria species. For prevention, it's taken once daily starting 1 to 2 days before travel to a malaria-endemic area and continuing for 7 days after return — a shorter pre- and post-travel window than some other antimalarials. The combination of two drugs with complementary mechanisms makes it harder for the malaria parasite to develop resistance. It's well tolerated and commonly used by travelers.

Dual antimalarial mechanisms

Atovaquone disrupts mitochondrial electron transport in malaria parasites, collapsing their energy production, while proguanil's active metabolite inhibits dihydrofolate reductase — blocking parasite DNA synthesis through a second independent pathway.

Resistance barrier

Targeting two essential parasite processes simultaneously makes it significantly harder for Plasmodium falciparum to develop drug resistance compared to single-agent antimalarials.

Convenient travel prevention schedule

Requires only 1 to 2 days of pre-travel dosing and 7 days post-travel — a much shorter chemoprophylaxis window than mefloquine (which requires weeks before and after travel), making it practical for last-minute travel plans.

Virtual visit with clinician

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

5 out of 5 stars on Trustpilot

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

5 out of 5 stars on Trustpilot

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

5 out of 5 stars on Trustpilot

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

5 out of 5 stars on Trustpilot

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

5 out of 5 stars on Trustpilot

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

5 out of 5 stars on Trustpilot

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

5 out of 5 stars on Trustpilot

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