General
Malarone (Proguanil - atovaquone)
Virtual visit

Malarone (Proguanil - atovaquone)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Malarone (Proguanil - atovaquone) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Malarone?

Malarone is a prescription antimalarial medication combining atovaquone and proguanil, used to both prevent and treat malaria caused by Plasmodium falciparum—the most dangerous malaria species. For prevention, it's taken once daily starting 1–2 days before travel to a malaria-endemic area and continuing for 7 days after return—a shorter pre- and post-travel window than some other antimalarials. The combination of two drugs with complementary mechanisms makes it highly effective and harder for the malaria parasite to develop resistance against. It's well-tolerated and a preferred choice for many travelers.

Dual antimalarial mechanisms

Atovaquone disrupts mitochondrial electron transport in malaria parasites, collapsing their energy production, while proguanil's active metabolite inhibits dihydrofolate reductase—blocking parasite DNA synthesis through a second independent pathway.

Resistance barrier

Targeting two essential parasite processes simultaneously makes it significantly harder for Plasmodium falciparum to develop drug resistance compared to single-agent antimalarials.

Convenient travel prevention schedule

Requires only 1–2 days of pre-travel dosing and 7 days post-travel—a much shorter chemoprophylaxis window than mefloquine (which requires weeks before and after travel), making it practical for last-minute travel plans.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

When should I start taking Malarone before travel?

Start Malarone 1–2 days before entering a malaria-endemic area. This much shorter lead time compared to older antimalarials like mefloquine — which requires weeks — makes it ideal for last-minute travel plans.

How long after returning home do I need to continue Malarone?

Continue taking Malarone once daily for 7 days after leaving the malaria-endemic area. This post-travel period is important because the medication needs to eliminate any malaria parasites acquired during exposure.

Is Malarone effective against all types of malaria?

Malarone is highly effective against Plasmodium falciparum — the most dangerous malaria species. Effectiveness varies for other species like P. vivax. Your clinician will advise based on your specific destination's malaria profile.

What side effects might I experience?

Nausea, stomach pain, headache, and vomiting are the most commonly reported effects. Taking Malarone with food or a milky drink significantly reduces GI side effects. These are generally mild and manageable.

Can Malarone be used for children?

Yes. Malarone is approved for malaria prevention in children weighing 11 kg or more and for treatment at 5 kg or more. Pediatric tablets are available in a smaller dose — always confirm weight-appropriate dosing with your clinician.
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