Low Dose Naltrexone

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Most insurance accepted

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Available nationwide

What is Low Dose Naltrexone?

Low Dose Naltrexone refers to using naltrexone — a medication FDA-approved at higher doses for alcohol and opioid use disorder — at a much smaller dose for off-label purposes, most commonly chronic pain conditions like fibromyalgia and certain autoimmune or inflammatory conditions. The evidence for these off-label uses is still developing, and response varies by person. It's typically taken once daily, usually at night.

Immune-modulating mechanism

At low doses, believed to briefly block opioid receptors, triggering a rebound increase in the body's own endorphins and modulating inflammation.

Distinct from standard-dose use

An off-label use at a fraction of the dose used for opioid addiction treatment, with a different mechanism and side-effect profile.

Typically taken at night

Usually dosed once daily at bedtime, since the temporary receptor blockade is best tolerated during sleep.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

Thousands of customers trust us

“I feel like I'm finally on the right path to improving my health with the right support now! It's so refreshing and reassuring.”

—Emerald, Texas

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

—Kaylee, Louisiana

“I couldn't be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

—Nika, Tennessee

Dive deeper: get the support you need

Your health rarely comes down to just one thing. If your clinician identifies related needs during your visit, we can help address them through additional services.

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Frequently asked questions

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General Medicine provides convenient care for all of your of health needs, including common and chronic conditions, specialist consultations, and preventative care. We make it easy to get the care you need—whether it's getting the right prescriptions, labs or imaging, or connecting you with the right specialists or in-person providers—ensuring your healthcare experience is seamless and stress-free.

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