Lokelma

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What is Lokelma?

Lokelma is a prescription medication used to treat hyperkalemia—abnormally high potassium levels in the blood—a potentially dangerous condition that can cause life-threatening cardiac arrhythmias. It works by trapping potassium ions in the gastrointestinal tract and removing them from the body through the stool, before they can be absorbed. Unlike older potassium binders, Lokelma has a highly specific and efficient binding structure that selectively captures potassium throughout the entire GI tract. It acts quickly—lowering potassium levels within hours—and can be used for both acute correction and ongoing maintenance to keep potassium in a safe range.

Selective potassium ion trapping

Lokelma's microporous zirconium silicate structure acts as an artificial ion exchanger, selectively capturing potassium ions (as well as ammonium and hydrogen ions) throughout the GI tract—removing them via the stool before absorption into the bloodstream.

Rapid onset potassium reduction

Begins lowering serum potassium within 1–2 hours of the first dose, making it one of the fastest-acting oral potassium-lowering agents—useful for both urgent correction of acute hyperkalemia and as maintenance therapy.

Maintenance tolerability

Unlike older potassium binders (like sodium polystyrene sulfonate) that have significant GI tolerability issues, Lokelma is generally well-tolerated for long-term daily use—important for patients with chronic kidney disease or heart failure who require ongoing potassium management.

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Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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