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Linzess (Linaclotide)
Virtual visit

Linzess (Linaclotide)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Linzess (Linaclotide) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Linzess (Linaclotide)?

Linzess is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation in adults. It works locally in the intestinal lining without being absorbed into the bloodstream, activating receptors that increase fluid secretion into the intestine and accelerate gut movement. This combination softens stool and helps it move more easily through the colon. Beyond constipation relief, Linzess also helps reduce the abdominal pain and discomfort associated with IBS-C. It's taken once daily on an empty stomach, 30 minutes before the first meal.

Guanylate cyclase-C activation

Binds to receptors in the intestinal lining, triggering a signaling cascade that increases chloride and water secretion into the gut—softening stool and creating the fluid environment needed for easier, more regular bowel movements.

Abdominal pain reduction

Beyond its laxative effect, Linzess reduces visceral hypersensitivity in the gut—the heightened pain signaling that makes the intestinal discomfort of IBS-C disproportionately severe.

Local gut action

Works entirely within the intestinal tract without entering the bloodstream in meaningful amounts, focusing its effects where they're needed while minimizing systemic side effects.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How quickly does Linzess work?

Many people experience their first bowel movement within 24 hours of the first dose. Consistent daily use is needed to maintain the effect — it works best when taken the same time each morning.

How should I take Linzess?

Take it on an empty stomach 30 minutes before your first meal of the day. Taking it with food increases the likelihood of loose stools — timing it before eating significantly improves tolerability.

Will Linzess also help my abdominal pain?

Yes. Linzess is approved for IBS-C specifically because it reduces both constipation and the abdominal pain and discomfort that accompany it — addressing more than just bowel movement frequency.

What side effects might I experience?

Diarrhea is the most common side effect and can range from mild to severe. If severe diarrhea occurs, stop taking it and contact your clinician. Abdominal pain, gas, and bloating can also occur.

Is Linzess safe for long-term use?

Linzess is approved for ongoing use in chronic idiopathic constipation and IBS-C. Long-term safety data supports continued use — your clinician will assess whether ongoing treatment remains appropriate at follow-up visits.
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