Linzess

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Most insurance accepted

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Available nationwide

What is Linzess?

Linzess is a prescription medication used to treat irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation in adults. It works locally in the intestinal lining without being absorbed into the bloodstream, activating receptors that increase fluid secretion into the intestine and accelerate gut movement. This combination softens stool and helps it move more easily through the colon. Beyond constipation relief, Linzess also helps reduce the abdominal pain and discomfort associated with IBS-C. It's taken once daily on an empty stomach, 30 minutes before the first meal.

Guanylate cyclase-C activation

Binds to receptors in the intestinal lining, triggering a signaling cascade that increases chloride and water secretion into the gut—softening stool and creating the fluid environment needed for easier, more regular bowel movements.

Abdominal pain reduction

Beyond its laxative effect, Linzess reduces visceral hypersensitivity in the gut—the heightened pain signaling that makes the intestinal discomfort of IBS-C disproportionately severe.

Local gut action

Works entirely within the intestinal tract without entering the bloodstream in meaningful amounts, focusing its effects where they're needed while minimizing systemic side effects.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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