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Lifitegrast (Xiidra)
Virtual visit

Lifitegrast (Xiidra)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Lifitegrast (Xiidra) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Lifitegrast (Xiidra)?

Xiidra is a prescription eye drop used to treat the signs and symptoms of dry eye disease, specifically targeting the underlying inflammatory process rather than simply lubricating the eye surface. It works by blocking LFA-1, a protein on the surface of immune cells that promotes inflammation in the tear glands and eye surface. By interrupting this inflammatory signaling, Xiidra reduces the immune-driven damage that disrupts tear production and eye surface health. It's applied twice daily and may take up to 12 weeks to produce the full benefit.

LFA-1 integrin blockade

Blocks the interaction between LFA-1 on T-lymphocytes and ICAM-1 on eye surface cells, preventing the immune cell activation and inflammatory cascade that damages the ocular surface and reduces tear production in dry eye disease.

Root-cause anti-inflammatory treatment

Rather than masking symptoms with artificial lubrication, Xiidra addresses the underlying inflammatory mechanism driving dry eye—improving both the symptoms patients feel and the clinical signs providers measure.

Dual symptom and sign improvement

Clinical trials demonstrated improvement in both patient-reported eye dryness and discomfort and objective measures of ocular surface damage—distinguishing it from lubricating drops that only relieve symptoms temporarily.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How long before Xiidra improves my dry eye symptoms?

Some patients notice symptom improvement within 2 weeks, but meaningful relief of both the symptoms and underlying inflammation typically takes 6–12 weeks of consistent twice-daily use.

How is Xiidra different from Restasis?

Both treat dry eye disease by addressing inflammation, but through different mechanisms. Xiidra blocks LFA-1, while Restasis uses cyclosporine. Some patients respond better to one than the other — clinicians may try both.

Do I need to use artificial tears alongside Xiidra?

Artificial tears can still be used for immediate symptom relief while Xiidra builds its anti-inflammatory effect. Wait at least 15 minutes between applying Xiidra and other eye drops.

What side effects might I experience?

Eye irritation, burning or stinging upon instillation, blurred vision shortly after application, and an unusual taste in the mouth after using the drops are the most commonly reported effects.

Can I wear contact lenses while using Xiidra?

Remove contact lenses before applying Xiidra and wait at least 15 minutes before reinserting them. The preservative in the drop can be absorbed by soft contact lenses and cause irritation.
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