Lialda

Brand for mesalamine

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Most insurance accepted

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Available nationwide

What is Lialda?

Lialda is a prescription extended-release Lialda tablet used to treat and maintain remission of mild to moderate ulcerative colitis. Lialda is an anti-inflammatory agent that works locally in the lining of the colon—where UC inflammation occurs—rather than systemically. Lialda's unique MMX multi-matrix delivery system releases the medication gradually throughout the entire colon, targeting the full extent of colonic inflammation with once-daily dosing. It's the first Lialda formulation approved for once-daily dosing, which simplifies the treatment regimen compared to older 3–4 times daily formulations.

Local colonic anti-inflammatory action

Lialda inhibits prostaglandin and leukotriene synthesis in the colonic mucosa, reducing the inflammation that causes the bloody diarrhea, cramping, and urgency of ulcerative colitis—with activity concentrated in the colon rather than systemically.

MMX extended-release delivery

Lialda's multi-matrix technology creates a hydrophilic and lipophilic matrix that releases Lialda progressively throughout the entire colon—ensuring drug reaches both the left and right colon where UC inflammation may be present.

Once-daily remission maintenance

Approved for once-daily dosing to induce and maintain remission, Lialda significantly reduces the daily pill burden compared to older Lialda formulations—improving long-term adherence in a condition that typically requires ongoing therapy.

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