Leucovorin

Without insurance

With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Leucovorin?

Leucovorin is a form of folinic acid—an active form of the B vitamin folate—used in medicine primarily to protect normal cells from the toxic effects of methotrexate chemotherapy (a process called leucovorin rescue), and to enhance the anti-cancer effectiveness of 5-fluorouracil in colorectal cancer treatment. It's also co-administered with pyrimethamine (Daraprim) to prevent the folate deficiency and bone marrow suppression that drug can cause. Unlike folic acid supplements, Leucovorin bypasses the enzyme that methotrexate blocks, allowing normal cells to maintain folate metabolism even during high-dose methotrexate therapy.

Methotrexate rescue

Leucovorin bypasses the dihydrofolate reductase enzyme that methotrexate inhibits, restoring folate-dependent metabolic pathways in normal tissues—protecting bone marrow, GI mucosa, and other rapidly dividing healthy cells from methotrexate toxicity after high-dose chemotherapy.

5-FU chemotherapy enhancement

Stabilizes the bond between 5-fluorouracil and thymidylate synthase, the enzyme 5-FU targets in cancer cells—increasing the duration and potency of 5-FU's DNA-blocking activity and improving its effectiveness in colorectal cancer treatment.

Folate pathway bypass

As a pre-reduced form of folate, Leucovorin can be directly used by cells without enzymatic activation—allowing normal folate metabolism to continue in situations where key folate enzymes are blocked by antifolate drugs or genetic defects.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

Thousands of customers trust us

“I feel like I'm finally on the right path to improving my health with the right support now! It's so refreshing and reassuring.”

—Emerald, Texas

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

—Kaylee, Louisiana

“I couldn't be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

—Nika, Tennessee

Dive deeper: get the support you need

Your health rarely comes down to just one thing. If your clinician identifies related needs during your visit, we can help address them through additional services.

Medications

We will write your prescription and send it to your pharmacy

Lab tests

See cost up front and book your lab test instantly

Dermatology

Get a specialist consult or talk to a clinician about your condition

Travel needs

Going on a big trip? Get the vaccines and medications you need

Everyday care

No waitlist, rushed visits, or hidden fees—get care fast.

Frequently asked questions

What is General Medicine?

What can General Medicine help with?

General Medicine provides convenient care for all of your of health needs, including common and chronic conditions, specialist consultations, and preventative care. We make it easy to get the care you need—whether it's getting the right prescriptions, labs or imaging, or connecting you with the right specialists or in-person providers—ensuring your healthcare experience is seamless and stress-free.

How much does General Medicine cost?

Who is the care team at General Medicine?

How do you protect my health information?