Logo
Januvia (sitagliptin)
Virtual visit

Januvia (sitagliptin)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Januvia (sitagliptin) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Januvia (sitagliptin)?

Januvia is a DPP-4 inhibitor used to improve blood sugar control in adults with Type 2 diabetes. It works by blocking the enzyme that breaks down incretin hormones—GLP-1 and GIP—allowing these natural hormones to remain active longer and stimulate insulin release in a glucose-dependent manner. This means Januvia only promotes insulin secretion when blood sugar is elevated, significantly reducing the risk of hypoglycemia compared to older diabetes medications. It's taken once daily as a tablet and is weight-neutral, making it a well-tolerated addition to existing diabetes regimens.

DPP-4 enzyme inhibition

Blocks dipeptidyl peptidase-4, the enzyme that rapidly degrades GLP-1 and GIP incretin hormones, extending their activity and allowing them to stimulate more insulin release and suppress glucagon in a glucose-dependent manner.

Glucose-dependent insulin stimulation

Because it works through incretin hormones that only activate insulin release when blood sugar is elevated, Januvia carries a low risk of hypoglycemia—unlike sulfonylureas that stimulate insulin regardless of current glucose levels.

Weight-neutral profile

Unlike some diabetes medications that cause weight gain, Sitagliptin has a neutral effect on body weight—an important consideration for Type 2 diabetes management where excess weight is often a contributing factor.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How does Januvia lower blood sugar differently from metformin?

Januvia works by inhibiting DPP-4 to extend the activity of natural incretin hormones — stimulating insulin release only when blood sugar is elevated. Metformin reduces liver glucose production and improves insulin sensitivity through entirely different pathways.

Does Januvia cause weight gain?

Januvia is weight-neutral — it neither causes weight gain nor promotes weight loss. This distinguishes it from sulfonylureas (which cause weight gain) and GLP-1 agonists (which often promote weight loss).

Can Januvia be used alongside other diabetes medications?

Yes. Januvia is frequently added to metformin, sulfonylureas, insulin, or other diabetes medications for additional blood sugar control. Dose adjustments of other medications may be needed when combining.

What side effects might I experience?

Upper respiratory infections, stuffy or runny nose, headache, and sore throat are the most commonly reported. Joint pain has been reported in some patients. Serious pancreatitis has been reported rarely — seek care for severe persistent abdominal pain.

Does Januvia require dose adjustment for kidney disease?

Yes. Unlike Tradjenta (linagliptin), sitagliptin is primarily cleared by the kidneys and requires dose reduction as kidney function declines. Your clinician will adjust the dose based on your eGFR.
Logo

© 2026 Path Healthcare Systems Corp.