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Indocin (indomethacin)
Virtual visit

Indocin (indomethacin)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Indocin (indomethacin) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Indocin (indomethacin)?

Indocin is a potent non-steroidal anti-inflammatory drug (NSAID) used to treat moderate to severe pain and inflammation in conditions including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gout flares, and bursitis. It's one of the most powerful NSAIDs available and is particularly valued for acute gout because of how rapidly and effectively it reduces the intense joint inflammation of a gout attack. It works by inhibiting COX-1 and COX-2 enzymes to reduce prostaglandin production. Because of its potency, it carries a higher risk of GI side effects than milder NSAIDs and is typically used at the lowest effective dose for the shortest duration.

Potent COX-1 and COX-2 inhibition

Blocks both cyclooxygenase isoforms with high potency, dramatically reducing prostaglandin synthesis and delivering powerful anti-inflammatory, analgesic, and antipyretic effects stronger than most other oral NSAIDs.

Acute gout flare management

Highly effective for the intense inflammatory arthritis of acute gout—Indomethacin's rapid onset and potent anti-inflammatory activity can significantly reduce the severe joint pain and swelling within hours of dosing.

Higher GI risk consideration

Its high COX-1 inhibitory activity reduces the protective prostaglandins in the gastric lining, making GI irritation, ulceration, and bleeding more likely than with less potent NSAIDs—taken with food and used for the shortest effective duration.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

What conditions is Indocin used for?

Indocin is a potent NSAID prescribed for acute gout attacks, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, and tendinitis — conditions where its high anti-inflammatory potency provides an advantage over milder NSAIDs.

How quickly does Indocin work for a gout attack?

For acute gout, meaningful pain relief typically begins within hours of the first dose. The rapid anti-inflammatory action makes it one of the most effective agents for stopping an acute gout flare quickly.

Should I take Indocin with food?

Yes — always take indomethacin with food, milk, or antacids. It has one of the highest rates of GI side effects among NSAIDs, and taking it with food significantly reduces the risk of stomach upset, ulceration, and bleeding.

What side effects might I experience?

Stomach pain, nausea, heartburn, dizziness, and headache are most common. Indocin has a higher rate of GI side effects than most other NSAIDs due to its non-selective COX inhibition — use at the lowest effective dose for the shortest time.

Can I take Indocin if I have kidney disease?

NSAIDs reduce kidney blood flow and should be used with caution or avoided in people with existing kidney disease. Indomethacin's high potency makes this consideration particularly important — discuss with your clinician.
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