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Inapryl (Trospium - xanomeline)
Virtual visit

Inapryl (Trospium - xanomeline)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Inapryl (Trospium - xanomeline) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Inapryl (Trospium - xanomeline)?

Inapryl is a prescription combination medication containing xanomeline, a muscarinic agonist, and trospium, an anticholinergic agent, used to treat schizophrenia in adults. Xanomeline targets the muscarinic receptors believed to play a role in the psychotic symptoms and cognitive deficits of schizophrenia—a fundamentally different approach from traditional antipsychotics that work on dopamine receptors. Trospium is added to block the peripheral side effects that xanomeline alone would cause in the body outside the brain. Together, they represent the first new class of schizophrenia treatment in decades.

Muscarinic receptor agonism

Xanomeline activates M1 and M4 muscarinic receptors in the brain, modulating the cholinergic and dopaminergic signaling implicated in both the positive symptoms (hallucinations, delusions) and cognitive deficits of schizophrenia—without directly blocking dopamine receptors.

Peripheral side effect mitigation

Trospium, which doesn't cross the blood-brain barrier, blocks the peripheral muscarinic receptors that xanomeline would otherwise activate outside the brain—preventing GI and cardiovascular side effects while preserving central therapeutic activity.

First-in-class mechanism

Inapryl is the first approved antipsychotic to work through the muscarinic rather than dopaminergic pathway, representing a landmark pharmacological breakthrough for a condition where dopamine-based treatments have been the only option for over 60 years.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
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Frequently Asked Questions

What makes Inapryl different from all other antipsychotic medications?

Inapryl is the first antipsychotic to work through the muscarinic system rather than by blocking dopamine receptors — the mechanism shared by all previous antipsychotics for over 60 years. This represents a fundamentally new approach to treating schizophrenia.

Why does Inapryl contain two medications?

Xanomeline activates muscarinic receptors in the brain to treat schizophrenia symptoms, but also activates peripheral muscarinic receptors causing GI and cardiovascular side effects. Trospium — which doesn't cross into the brain — blocks only those peripheral effects.

How quickly does Inapryl start working?

Clinical trials showed meaningful reductions in both positive symptoms (hallucinations, delusions) and negative symptoms within 5 weeks of treatment. Your clinician will monitor response over the first several weeks.

What side effects might I experience?

Nausea, constipation, vomiting, dyspepsia, dizziness, hypertension, and abdominal pain are the most commonly reported effects. The trospium component reduces but doesn't eliminate peripheral anticholinergic-type side effects from xanomeline.

Is Inapryl appropriate for people who haven't responded to other antipsychotics?

Yes. Because Inapryl works through an entirely different mechanism than dopamine-blocking antipsychotics, it offers a clinically meaningful alternative for patients who haven't responded adequately to existing treatments.
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