Hyzaar

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What is Hyzaar?

Hyzaar is a combination blood pressure medication containing losartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide (HCTZ), a thiazide diuretic. Together, they lower blood pressure through two complementary mechanisms—losartan blocks vasoconstriction from angiotensin II while HCTZ reduces blood volume through increased kidney excretion of salt and water. The combination also helps counteract some of each drug's side effects: HCTZ tends to raise potassium loss, while losartan tends to retain it. It's taken once daily and is appropriate for patients who need dual therapy to achieve blood pressure control.

Dual angiotensin blockade and diuresis

Losartan blocks AT1 receptors to prevent angiotensin II-driven vasoconstriction, while hydrochlorothiazide reduces circulating blood volume by inhibiting sodium reabsorption in the kidney—attacking high blood pressure through two independent and additive mechanisms.

Complementary electrolyte balance

HCTZ causes potassium loss, while Losartan's aldosterone-blocking effect tends to conserve potassium—the two effects partially offset each other, producing a more balanced electrolyte profile than HCTZ used alone.

Stroke risk reduction in hypertension with LVH

Hyzaar has specific clinical trial evidence for reducing stroke risk in hypertensive patients with left ventricular hypertrophy—a cardiovascular benefit that extends beyond blood pressure lowering alone.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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