General
Hiprex (methenamine)
Virtual visit

Hiprex (methenamine)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Hiprex (methenamine) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Hiprex (methenamine)?

Hiprex is a prescription urinary antiseptic used for the long-term prevention of recurring urinary tract infections (UTIs) in patients who experience frequent infections. It works differently from antibiotics—rather than killing bacteria directly, it releases formaldehyde in acidic urine, which creates a hostile environment that suppresses bacterial growth in the bladder. Because it works locally in the urinary tract and doesn't enter systemic circulation significantly, it avoids the antibiotic resistance concerns associated with long-term antibiotic use. It's taken twice daily and works best when urine is kept acidic.

Formaldehyde conversion

Methenamine is converted to formaldehyde in acidic urine, creating a bacteriostatic environment within the bladder that inhibits bacterial growth and adherence without systemic antibiotic exposure.

Resistance-sparing prevention

Because it doesn't work as a traditional antibiotic, long-term Hiprex use doesn't contribute to antibiotic resistance—a major advantage over continuous low-dose antibiotic prophylaxis for recurrent UTIs.

Urine acidification dependency

Works best when urinary pH is low. Vitamin C or other acidifying agents are sometimes used alongside Hiprex to maintain the acidic urine environment needed for optimal formaldehyde release.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

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Get the care you need, without the wait.

Frequently Asked Questions

How is Hiprex different from antibiotic UTI prevention?

Hiprex prevents UTIs through a non-antibiotic mechanism — it releases formaldehyde in acidic urine, creating a hostile environment for bacteria. It does not contribute to antibiotic resistance, unlike long-term antibiotic prophylaxis.

How acidic does my urine need to be for it to work?

Hiprex requires urine pH below 6 to generate effective formaldehyde levels. Your clinician may recommend vitamin C or other acidifying agents alongside Hiprex to help maintain the required urine acidity.

How long before it starts preventing UTIs?

Hiprex works as an ongoing preventive taken twice daily — it maintains a continuously bacteriostatic urine environment rather than treating active infections. Regular use over weeks to months is needed to assess its effectiveness.

What side effects might I experience?

Nausea, stomach upset, and bladder irritation are the most commonly reported side effects. High doses can cause more pronounced GI discomfort. These are generally mild and manageable at standard therapeutic doses.

Can Hiprex be used during pregnancy?

Hiprex is generally avoided in the first trimester and used cautiously thereafter. If you are pregnant or planning pregnancy, discuss the risks and benefits carefully with your clinician before continuing use.
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