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Gralise (Gabapentin)
Virtual visit

Gralise (Gabapentin)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Gralise (Gabapentin) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Gralise (Gabapentin)?

Gralise is an extended-release formulation of gabapentin specifically approved for managing postherpetic neuralgia—the persistent nerve pain that can follow a shingles outbreak. Unlike immediate-release gabapentin, Gralise is designed to be taken once daily with the evening meal, using a gradual-release mechanism that delivers the medication steadily throughout digestion. It works by calming overactive nerve signals that misfire and cause burning, shooting, or electric-like pain long after the shingles rash has healed.

Nerve signal modulation

Binds to calcium channels in overactive nerve cells, reducing the abnormal firing that causes the chronic burning and shooting pain characteristic of postherpetic neuralgia.

Extended-release design

Gralise's unique delivery system releases gabapentin gradually as it moves through the GI tract, maintaining more consistent blood levels than immediate-release formulations with once-daily dosing.

Targeted indication

Formulated specifically for postherpetic neuralgia—not interchangeable with other gabapentin products—allowing for a dosing schedule optimized for this particular type of nerve pain.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How is Gralise different from regular gabapentin?

Gralise is extended-release gabapentin specifically approved for postherpetic neuralgia. Unlike standard gabapentin taken multiple times daily, Gralise is taken once with the evening meal for more consistent overnight coverage.

How long until it helps my nerve pain?

Some improvement may appear within 1–2 weeks, but meaningful pain relief often takes 3–4 weeks of consistent use at an effective dose, which is increased gradually over several weeks.

Can I crush or split Gralise tablets?

No. Gralise tablets must be swallowed whole. Crushing, splitting, or chewing destroys the extended-release mechanism and results in too much medication being absorbed too quickly.

What side effects might I experience?

Dizziness and drowsiness are most common, particularly at higher doses and often improving over time. Unsteadiness and blurred vision can also occur — especially in older adults who may be more sensitive.

Is Gralise interchangeable with other gabapentin products?

No. Gralise is formulated specifically for postherpetic neuralgia and is not interchangeable with immediate-release gabapentin or Horizant. Substituting one for another requires clinician-guided dose recalculation.
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